The innate immune response to non-infectious stressors : human and animal models / edited by Massimo Amadori.

Includes bibliographical references and index.

Online resource; title from PDF title page (EBSCO, viewed March 17, 2016).

The Innate Immune Response to Non-infectious Stressors: Human and Animal Models highlights fundamental mechanisms of stress response and important findings on how the immune system is affected, and in turn affects such a response. In addition, this book covers the crucial link between stress response and energy metabolism, prompts a re-appraisal of some crucial issues, and helps to define research priorities in this fascinating, somehow elusive field of investigation.

Cover; Title Page; Copyright Page; Dedication; Contents; Contributors; Preface; References; Chapter 1 -- An Overview of the Innate Immune Response to Infectious and Noninfectious Stressors; Introduction; Recognition; PRRs and PAMPs; Toll-Like Receptors; Signaling; C-Type Lectin Receptors; Signaling; The RIG-I-Like Receptors; Signaling; NLRs and the Inflammasome; Signaling; AIM2-Like Receptors; Signaling; C-GAS and Other DNA Sensors; Signaling; RAGE; Soluble PRRs; PRR localization; DAMPs; Nucleic Acids; ATP; Uric Acid; Heat-Shock Proteins; Mitochondrial Danger Signals; HMGB1; DAMP; Chaperone.

Secondary Danger SignalChemokine; Redox State; Degradation Products of the Extracellular Matrix; Secondary endogenous danger signals; Emerging and Homeostatic Danger Signals; Conclusions; References; Chapter 2 -- Homeostatic Inflammation as Environmental-Adaptation Strategy; Introduction; Innate immune sensors recognize various endogenous ligands including metabolites; Modulation of metabolites recognized by extracellular sensors; Modification of nucleic acid-sensing receptors; DNA and RNA are modified to be recognized or not by innate immune sensors.

Priming effect of noninfectious inflammation on immune responseCorrelation with inflammatory and autoimmune diseases in adipose tissue; Excessive activation of nucleic acid-sensing sensors induces autoimmune diseases; Regulation of homeostatic inflammation and innate immune sensors for controlling immune system and homeostasis; References; Chapter 3 -- The Molecular Basis of the Immune Response to Stressed Cells and Tissues; Innate immune responses: receptors and ligands; Stress-mediated regulation of immune receptors and ligands: an overview.

Transcriptional Regulation of NK-Cell Activating Ligands Modulated by Stress ResponsesPosttranscriptional Regulation of Stress-Controlled NK-Cell Activating Ligands; Translational and Posttranslational Regulation of Stress-Modulated NK-Cell Activating Ligands; Different forms of stress regulate innate immunity; Osmotic Stress; Thermal Stress; Genotoxic Stress; Oxidative Stress; Endoplasmic Reticulum Stress; Stress-Induced Senescence; Immunogenic cell death: putting all the things together; References; Chapter 4 -- Modulation of Innate Immunity by Hypoxia; Hypoxia; Hypoxia sensing.

Hypoxia-Inducible FactorsNuclear Factor kB; Hypoxia effects on leukocytes; Myeloid Cells; Monocytes/Macrophages; Granulocytes; Dendritic Cells; Lymphoid Cells; Hypoxia, myeloid cells, and diseases; Pulmonary Hypertension (PH); Rheumatoid Arthritis; Inflammatory Bowel Disease; Atherosclerosis; Ischemia; Preeclampsia; Allergy; Cancer; Therapeutic targeting of hypoxic signaling; HIF Activators; HIF Inhibitors; Acknowledgments; References; Chapter 5 -- Metabolic Stress, Heat Shock Proteins, and Innate Immune Response; Introduction; Metabolic stress conditions; Metabolic stress and innate immunity.