000			04869cam a2200493Ki 4500
001			ocn962411860
003			OCoLC
005			20190719103352.0
006			m o d
007			cr cnu---unuuu
008			161109s2017 enk o 000 0 eng d
040			_aIDEBK _beng _erda _epn _cIDEBK _dN$T _dYDX _dEBLCP _dNLE _dOCLCO _dOPELS _dN$T _dOCLCF _dOCLCQ _dOTZ _dIDEBK _dOCLCQ _dU3W _dMERUC _dD6H _dYDX _dOCLCO _dMERER _dOCLCQ
019			_a962303012 _a962326192
020			_a9780128028032 _q(electronic book)
020			_a0128028033 _q(electronic book)
020			_z0128027924
020			_z9780128027929
035			_a(OCoLC)962411860 _z(OCoLC)962303012 _z(OCoLC)962326192
050		4	_aQP88.2 _b.M38 2017
072		7	_aMED _x085000 _2bisacsh
082	0	4	_a617.471 _223
245	0	0	_aMaterials and devices for bone disorders / _cedited by Susmita Bose, Amit Bandyopadhyay.
264		1	_aLondon, United Kingdom ; _aSan Diego, CA : _bAcademic Press, _c[2017]
300			_a1 online resource
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
505	0		_aFront Cover; Materials and Devices for Bone Disorders; Copyright Page; Contents; List of Contributors; Biography; Preface; 1 Introduction to Biomaterials and Devices for Bone Disorders; 1.1 Introduction; 1.2 Metallic Biomaterials; 1.3 Ceramic Biomaterials; 1.4 Polymeric Biomaterials; 1.5 Composite Biomaterials; 1.6 Additive Manufacturing (AM) of Biomaterials; 1.7 Biomaterials in Orthopedic Implants Devices; 1.7.1 Joint replacements; 1.7.2 Implants used in osteosynthesis for stabilization and fracture repair; 1.7.3 Spine implants; 1.7.4 Nonconventional implants for bone tumor.
505	8		_a1.7.5 Multifunctional devices1.8 Summary and Future Directions; Acknowledgments; References; 2 Bone Biology and Effects of Pharmaceutical Intervention on Bone Quality; 2.1 Bone Biology; 2.1.1 Bone functions; 2.1.2 Composition; 2.1.3 Architecture; 2.1.4 Bone cells; 2.1.4.1 Osteoclasts; 2.1.4.2 Osteoblast lineage; 2.1.4.2.1 The Wnt-signaling system; 2.1.4.3 Preosteoblasts; 2.1.4.4 Reversal cells; 2.1.4.5 Mature osteoblasts; 2.1.4.6 Lining cells; 2.1.4.7 Osteocytes; 2.1.5 Bone remodeling; 2.1.5.1 The basic multicellular unit; 2.1.5.2 Sequence of bone remodeling; 2.1.5.2.1 Origination.
505	8		_a2.1.5.2.2 Activation2.1.5.2.3 Resorption; 2.1.5.2.4 Reversal; 2.1.5.2.5 Formation; 2.1.5.2.6 Mineralization; 2.1.5.2.7 Reestablishing osteocyte network; 2.1.5.2.8 Quiescence; 2.1.6 Fracture repair; 2.1.6.1 Stress fractures; 2.1.6.2 Complete fractures; 2.1.7 Aspects of bone strength; 2.1.7.1 Bone shape; 2.1.7.2 Bone volume; 2.1.7.3 Mineralization density; 2.1.7.4 Microarchitecture; 2.1.7.5 Collagen structure; 2.1.7.6 Ability to repair damage; 2.1.7.7 Crystal characteristics; 2.1.7.8 Bone marrow; 2.1.7.9 Overall bone strength; 2.2 Pharmaceutical Intervention.
505	8		_a2.2.1 Bone loss with aging or disease2.2.2 Actions of systemic hormones and local cytokines; 2.2.2.1 Estrogen; 2.2.2.2 Glucocorticosteroids; 2.2.2.3 Thyroid; 2.2.2.4 Parathyroid; 2.2.2.5 Calcitonin; 2.2.2.6 1,25 (OH)2-Cholecalciferol (1,25D); 2.2.2.7 Insulin and insulin-like growth factor; 2.2.2.8 Serotonin; 2.2.2.9 Local cytokines; 2.2.3 Calcium supplementation; 2.2.4 Bone formation with osteoporosis medications; 2.2.5 Raloxifene; 2.2.6 Bisphosphonates; 2.2.6.1 Short-term effects; 2.2.6.2 Long-term effects; 2.2.6.3 Fracture healing; 2.2.7 Denosumab; 2.2.8 Teriparatide; 2.2.9 Strontium.
505	8		_a2.2.10 Emerging therapies2.2.10.1 Cathepsin K inhibitors; 2.2.10.2 Romosozumab; 2.2.11 Other medications or substances that affect bone strength; 2.2.11.1 Anticonvulsants; 2.2.11.2 Selective serotonin reuptake inhibitors; 2.2.11.3 Carbonic anhydrase inhibitors; 2.2.11.4 Thiazide diuretics; 2.2.11.5 Rosiglitazone; 2.2.11.6 Bortezomib; 2.2.11.7 Lithium; 2.2.11.8 Elements toxic to the bone; 2.2.11.9 Fluoride; 2.3 Summary; References; 3 Bone Disorders; 3.1 Introduction; 3.2 Metabolic Diseases; 3.2.1 Osteoporosis; 3.2.2 Paget's disease; 3.3 Degenerative Disc Disease; 3.4 Osteoarthritis.
588	0		_aOnline resource; title from digital title page (viewed on October 26, 2018).
650		0	_aBones _xMechanical properties.
650		0	_aBones _xDiseases _xTreatment.
650		7	_aMEDICAL _xSurgery _xGeneral. _2bisacsh
650		7	_aBones _xDiseases _xTreatment. _2fast _0(OCoLC)fst00836014
650		7	_aBones _xMechanical properties. _2fast _0(OCoLC)fst00836023
655		4	_aElectronic books.
700	1		_aBose, Susmita, _eeditor.
700	1		_aBandyopadhyay, Amit, _eeditor.
776	0	8	_iPrint version: _tMaterials and devices for bone disorders. _dLondon, United Kingdom ; San Diego, CA : Academic Press, [2017] _z0128027924 _z9780128027929 _w(OCoLC)954535271
856	4	0	_3ScienceDirect _uhttp://www.sciencedirect.com/science/book/9780128027929
999			_c504274 _d504209