000			05986cam a2200709Ii 4500
001			ocn941779213
003			OCoLC
005			20190719103215.0
006			m o d
007			cr cnu|||unuuu
008			160229t20162016ne ob 001 0 eng d
040			_aN$T _beng _erda _epn _cN$T _dYDXCP _dIDEBK _dCDX _dN$T _dOPELS _dOCLCF _dHMS _dCOO _dEBLCP _dD6H _dU3G _dOCLCQ _dESU _dOCLCQ _dOCLCO _dU3W _dWYU _dOCLCO _dOCLCA _dMERER
066			_cZsym
016	7		_a101682941 _2DNLM
019			_a945612137 _a958095726 _a1066467360
020			_a9780128019740 _q(electronic bk.)
020			_a0128019743 _q(electronic bk.)
020			_a0128019689
020			_a9780128019689
020			_z9780128019689
035			_a(OCoLC)941779213 _z(OCoLC)945612137 _z(OCoLC)958095726 _z(OCoLC)1066467360
050		4	_aRC108
060		4	_aQW 541
072		7	_aHEA _x039000 _2bisacsh
072		7	_aMED _x014000 _2bisacsh
072		7	_aMED _x022000 _2bisacsh
072		7	_aMED _x112000 _2bisacsh
072		7	_aMED _x045000 _2bisacsh
082	0	4	_a616/.044 _223
245	0	4	_aThe innate immune response to non-infectious stressors : _bhuman and animal models / _cedited by Massimo Amadori.
264		1	_aAmsterdam : _bAcademic Press is an imprint of Elsevier, _c[2016]
264		4	_c�2016
300			_a1 online resource
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
504			_aIncludes bibliographical references and index.
588	0		_aOnline resource; title from PDF title page (EBSCO, viewed March 17, 2016).
520			_aThe Innate Immune Response to Non-infectious Stressors: Human and Animal Models highlights fundamental mechanisms of stress response and important findings on how the immune system is affected, and in turn affects such a response. In addition, this book covers the crucial link between stress response and energy metabolism, prompts a re-appraisal of some crucial issues, and helps to define research priorities in this fascinating, somehow elusive field of investigation.
505	0		_aCover; Title Page; Copyright Page; Dedication; Contents; Contributors; Preface; References; Chapter 1 -- An Overview of the Innate Immune Response to Infectious and Noninfectious Stressors; Introduction; Recognition; PRRs and PAMPs; Toll-Like Receptors; Signaling; C-Type Lectin Receptors; Signaling; The RIG-I-Like Receptors; Signaling; NLRs and the Inflammasome; Signaling; AIM2-Like Receptors; Signaling; C-GAS and Other DNA Sensors; Signaling; RAGE; Soluble PRRs; PRR localization; DAMPs; Nucleic Acids; ATP; Uric Acid; Heat-Shock Proteins; Mitochondrial Danger Signals; HMGB1; DAMP; Chaperone.
505	8		_aSecondary Danger SignalChemokine; Redox State; Degradation Products of the Extracellular Matrix; Secondary endogenous danger signals; Emerging and Homeostatic Danger Signals; Conclusions; References; Chapter 2 -- Homeostatic Inflammation as Environmental-Adaptation Strategy; Introduction; Innate immune sensors recognize various endogenous ligands including metabolites; Modulation of metabolites recognized by extracellular sensors; Modification of nucleic acid-sensing receptors; DNA and RNA are modified to be recognized or not by innate immune sensors.
505	8		_aPriming effect of noninfectious inflammation on immune responseCorrelation with inflammatory and autoimmune diseases in adipose tissue; Excessive activation of nucleic acid-sensing sensors induces autoimmune diseases; Regulation of homeostatic inflammation and innate immune sensors for controlling immune system and homeostasis; References; Chapter 3 -- The Molecular Basis of the Immune Response to Stressed Cells and Tissues; Innate immune responses: receptors and ligands; Stress-mediated regulation of immune receptors and ligands: an overview.
505	8		_aTranscriptional Regulation of NK-Cell Activating Ligands Modulated by Stress ResponsesPosttranscriptional Regulation of Stress-Controlled NK-Cell Activating Ligands; Translational and Posttranslational Regulation of Stress-Modulated NK-Cell Activating Ligands; Different forms of stress regulate innate immunity; Osmotic Stress; Thermal Stress; Genotoxic Stress; Oxidative Stress; Endoplasmic Reticulum Stress; Stress-Induced Senescence; Immunogenic cell death: putting all the things together; References; Chapter 4 -- Modulation of Innate Immunity by Hypoxia; Hypoxia; Hypoxia sensing.
505	8		_aHypoxia-Inducible FactorsNuclear Factor kB; Hypoxia effects on leukocytes; Myeloid Cells; Monocytes/Macrophages; Granulocytes; Dendritic Cells; Lymphoid Cells; Hypoxia, myeloid cells, and diseases; Pulmonary Hypertension (PH); Rheumatoid Arthritis; Inflammatory Bowel Disease; Atherosclerosis; Ischemia; Preeclampsia; Allergy; Cancer; Therapeutic targeting of hypoxic signaling; HIF Activators; HIF Inhibitors; Acknowledgments; References; Chapter 5 -- Metabolic Stress, Heat Shock Proteins, and Innate Immune Response; Introduction; Metabolic stress conditions; Metabolic stress and innate immunity.
650		0	_aChronic diseases.
650		0	_aImmune response.
650		7	_aHEALTH & FITNESS _xDiseases _xGeneral. _2bisacsh
650		7	_aMEDICAL _xClinical Medicine. _2bisacsh
650		7	_aMEDICAL _xDiseases. _2bisacsh
650		7	_aMEDICAL _xEvidence-Based Medicine. _2bisacsh
650		7	_aMEDICAL _xInternal Medicine. _2bisacsh
650		7	_aChronic diseases. _2fast _0(OCoLC)fst00860072
650		7	_aImmune response. _2fast _0(OCoLC)fst00967867
650	1	2	_aChronic Disease.
650	1	2	_aImmunity, Innate.
655		0	_aElectronic book.
655		4	_aElectronic books.
700	1		_aAmadori, Massimo, _eeditor.
776	0	8	_iPrint version: _tInnate immune response to non-infectious stressors : human and animal models. _dAmsterdam, [Netherlands] : Academic Press, �2016 _hxxvii, 247 pages _z9780128019689
856	4	0	_3ScienceDirect _uhttp://www.sciencedirect.com/science/book/9780128019689
880		4	_6264-00 _c�2016
999			_c503843 _d503778