TY  - BOOK
AU  - Ham,Bryan M.
ED  - Wiley InterScience (Online service)
TI  - Proteomics of biological systems: protein phosphorylation using Mass spectrometry techniques 
SN  - 9781118137048
AV  - QP519.9.M3 H367 2012
U1  - 572/.62 23
PY  - 2012///]
CY  - Hoboken, N.J.
PB  - John Wiley & Sons
KW  - Proteomics
KW  - Methodology
KW  - Phosphorylation
KW  - Research
KW  - Phosphoproteins
KW  - Synthesis
KW  - Mass spectrometry
KW  - SCIENCE
KW  - Life Sciences
KW  - Biochemistry
KW  - bisacsh
KW  - Science
KW  - fast
KW  - Electronic resource
KW  - Electronic books
KW  - local
N1  - Includes bibliographical references and index; Posttranslational Modification (PTM) of Proteins -- Glycosylation of Proteins -- Sulfation of Proteins as Posttranslational Modification -- Eukaryote PTM as Phosphorylation: Normal State Studies -- Eukaryote PTM as Phosphorylation: Perturbed State Studies -- Prokaryotic Phosphorylation of Serine, Threonine, and Tyrosine -- Prokaryotic Phosphorylation of Histidine -- Appendix I: Atomic Weights and Isotopic Compositions -- Appendix II: Periodic Table of the Elements -- Appendix III: Fundamental Physical Constants
N2  - Phosphorylation is the addition of a phosphate (PO₄) group to a protein or other organic molecule. Phosphorylation activates or deactivates many protein enzymes, causing or preventing the mechanisms of diseases such as cancer and diabetes. This book shows how to use mass spectrometry to determine whether or not a protein has been correctly modified by the addition of a phosphate group. It also provides a combination of detailed, step-by-step methodology for phosphoproteomic sample preparation, mass spectral instrumental analysis, and data interpretation approaches. Furthermore, it includes the use of bioinformatic Internet tools such as the Blast2GO gene ontology (GO) tool, used to help understand and interpret complex data collected in these studies
UR  - https://doi.org/10.1002/9781118137048
ER  -