Genetic effects on environmental vulnerability to disease / edited by Michael Rutter.
Material type:
TextSeries: Novartis Foundation symposium ; 293.Publisher: Chicester, England ; Hoboken, N.J. : Wiley-Blackwell, 2008Description: 1 online resource (viii, 223 pages) : illustrationsContent type: text Media type: computer Carrier type: online resourceISBN: 9780470696781; 0470696788; 9780470696798; 0470696796Subject(s): Disease susceptibility -- Genetic aspects -- Congresses | Environmentally induced diseases -- Genetic aspects -- Congresses | Environmental Exposure -- adverse effects | Disease Susceptibility -- etiology | Genetic Predisposition to Disease -- genetics | HEALTH & FITNESS -- Diseases -- Genetic | MEDICAL -- Genetics | Environmental vulnerability | Genetic effects | Gene-environment interactions | Disease | DisorderGenre/Form: Congresses. | Electronic books.Additional physical formats: Print version:: Genetic effects on environmental vulnerability to disease.DDC classification: 616.042 LOC classification: R850.A2 | N69 v.293 2007NLM classification: WA 30.5 G328 2008Online resources: Wiley Online Library | Item type | Current library | Call number | Status | Date due | Barcode |
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Ebooks
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Mysore University Main Library | Not for loan | EBJW765 |
Proceedings of the Novartis Foundation Symposium on Understanding How Gene-Environment Interactions Work to Predict Disorder: A Lifecourse Approach, held at the University of Central Otago, Dunedin, N.Z., Nov. 8-9, 2007.
Includes bibliographical references and indexes.
Introduction : whither gene-environment interactions?? Michael Rutter -- Gene-environment interaction : overcoming methodological challenges / Rudolf Uher -- Gene-environment interaction and behavioral disorders : a developmental perspective based on endophenotypes / Marco Battaglia, Cecilia Marino, Michel Maziade, Massimo Molteni and Francesca D'Amato -- Use of monozygotic twins to investigate the relationship between 5HTTLPR genotype, depression and stressful life events : an application of item response theory / Naomi R. Wray, William L. Coventry, Michael R. James, Grant W. Montgomery, Lindon J. Eaves and Nicholas G. Martin -- Role of gene-stress interactions in gene finding studies / Harold Snieder, Xiaoling Wang, Vasiliki Lagou, Brenda W.J.H. Penninx, Harriëtte Riese and Catharina A. Hartman -- Practice and public policy in the era of gene-environment interactions / Kenneth A. Dodge -- Gene-environment interaction and the metabolic syndrome / Kristi B. Adamo and Frédérique Tesson -- Longitudinal studies of gene-environment interaction in common diseases -- good value for money? / Stephen P. Robertson and Richie Poulton -- Gene-environment interactions in breast cancer / Kee-Seng Chia -- Unbiased forward genetics and systems biology approaches to understanding how gene-environment interactions work to predict susceptibility and outcomes of infections / Malak Kotb, Nourtan Fathey, Ramy Aziz, Sarah Rowe, Robert W. Williams and Lu Lu -- Gene-environment interactions in environmental lung diseases / Steven R. Kleeberger and Hye-Youn Cho -- Gene-environment interaction in complex diseases : asthma as an illustrative case / Fernando D. Martinez -- Conclusions : taking stock and looking ahead / Michael Rutter.
Much research has attempted to show direct linear relations between genes and disorder. However, scientists have been discouraged by inconsistent findings based on this simple gene-phenotype approach. The alternative approach is to incorporate information about the environment. A gene-environment interaction approach assumes that environmental pathogens cause disorder, whereas genes influence susceptibility to environmental pathogens. This book brings together contributions from experts from multiple disciplines who discuss:.:.; How epidemiological cohort studies can better integrate physiolog.
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