Wellcome

Viral proteases and their inhibitors / edited by Satya P. Gupta.

Contributor(s): Gupta, Satya PrakashMaterial type: TextTextPublication details: London, United Kingdom : Academic Press is an imprint of Elsevier, [2017]Description: 1 online resourceContent type: text Media type: computer Carrier type: online resourceISBN: 0128096829; 9780128096826Subject(s): Viral proteinases -- Inhibitors | Virus inhibitors | Antiviral agents | HEALTH & FITNESS -- Diseases -- General | MEDICAL -- Clinical Medicine | MEDICAL -- Diseases | MEDICAL -- Evidence-Based Medicine | MEDICAL -- Internal Medicine | Antiviral agents | Virus inhibitors | Antiviral Agents -- therapeutic use | Protease Inhibitors -- therapeutic use | Peptide Hydrolases -- physiology | Viruses -- drug effectsGenre/Form: Electronic books. | Electronic book.DDC classification: 616.92 LOC classification: QR462NLM classification: 2017 H-086 | QV 268.5Online resources: ScienceDirect | ScienceDirect
Contents:
Cover; Title Page; Copyright Page; Contents; Contributors; Preface; Chapter 1 -- Fundamentals of Viruses and Their Proteases; 1 -- Introduction; 2 -- Biochemistry of proteases; 3 -- Viruses; 3.1 -- Enveloped/Nonenveloped Viruses; 3.2 -- DNA and RNA Viruses; 4 -- Viruses containing proteases; 4.1 -- Adenoviruses; 4.1.1 -- Adenovirus Protease; 4.2 -- Alphaviruses; 4.3 -- Flaviviruses; 4.3.1 -- NS2B-NS3 Protease; 4.3.2 -- NS3 NTPase/RNA Helicase (NS3hel); 4.4 -- Hepatitis C Virus; 4.4.1 -- HCV Protease; 4.5 -- Herpes Viruses; 4.5.1 -- Herpesvirus Protease; 4.6 -- Human Immunodeficiency Virus of Type 1.
4.6.1 -- HIV1 Protease4.7 -- Picornaviruses; 4.7.1 -- Picornavirus Proteases; 5 -- Conclusions; References; Further Reading; Chapter 2 -- Design and Development of Some Viral Protease Inhibitors by QSAR and Molecular Modeling Studies; 1 -- Introduction; 2 -- Quantitative structure-activity relationship; 3 -- Viral proteases; 3.1 -- Adenoviruses; 3.1.1 -- Adenovirus Protease AVP (Adenain) Structure and Function; 3.1.2 -- Adenoviral Protease AVP (Adenain) Inhibitors; 3.2 -- Hepatitis C Virus; 3.2.1 -- NS3 Protease Structure and Function; 3.2.2 -- NS3 Protease Inhibitors; 3.3 -- Human-Immunodeficiency Virus.
3.3.1 -- HIV Protease Structure and Function3.3.2 -- HIV Protease Inhibitors; 3.4 -- Picornavirus; 3.4.1 -- Picornavirus Protease Structure and Function; 3.4.2 -- Picornavirus Protease Inhibitors; 4 -- Conclusions; References; Further reading; Chapter 3 -- Advances in Studies on Adenovirus Proteases and Their Inhibitors; 1 -- Introduction; 2 -- Adenovirus life cycle; 3 -- Adenovirus maturation protease; 4 -- Structure of AVP; 5 -- AVP inhibitors; 6 -- Conclusions; References; Chapter 4 -- Alphavirus Nonstructural Proteases and Their Inhibitors; 1 -- Introduction; 2 -- Alphaviruses; 2.1 -- Life Cycle of Virus.
2.2 -- Alphavirus and its Virion Structure3 -- Global vision of nonstructural proteins; 3.1 -- NSP1 Protease Inhibitors; 3.1.1 -- Bone Marrow Stromal Antigen-2-Based Inhibitors; 3.1.2 -- Small Hairpin RNA Molecules; 3.2 -- NSP2 Inhibitors; 3.2.1 -- Natural Inhibitors; 3.2.2 -- Druggable Targets Peptides; 3.2.3 -- NSP2-Based High-Throughput Screening; 3.2.4 -- Thienopyrrole Derivatives; 3.2.5 -- Thiazolidone Derivatives; 3.3 -- NSP3 Protease Inhibitors; 3.3.1 -- Natural Inhibitors for NSP3 Protease; 3.4 -- NSP4 Protease Inhibitors; 3.4.1 -- Nucleoside and Nonnucleoside Inhibitors.
4 -- Concluding remarks and future perspectivesAcknowledgments; References; Further Reading; Chapter 5 -- Structure and Function of Alphavirus Proteases; 1 -- Introduction; 2 -- Alphavirus proteases; 3 -- Capsid protease; 3.1 -- Proteolytic Mechanism; 3.2 -- Structure of Capsid Protease; 3.2.1 -- The Hydrophobic Pocket; 3.2.2 -- The Catalytic Triad; 3.2.3 -- The Oxyanion Hole; 3.2.4 -- Specificity Pockets; 3.3 -- trans-Protease Activity and High Throughput Inhibitor Screening Assay; 3.4 -- Capsid Protease Inhibition; 4 -- nsP2 protease; 4.1 -- Mechanism; 4.2 -- Crystal Structures of nsP2 Protease.
4.2.1 -- VEEV nsP2 Protease Structure.
Summary: Viral Proteases and Their Inhibitors provides a thorough examination of viral proteases from their molecular components, to therapeutic applications. As information on three dimensional structures and biological functions of these viral proteases become known, unexpected protein folds and unique mechanisms of proteolysis are realized. This book investigates how this facilitates the design and development of potent antiviral agents used against life-threatening viruses. Users will find descriptions of each virus that detail the structure and function of viral proteases, discuss the design and development of inhibitors, and analyze the structure-activity relationships of inhibitors. This book is ideal biochemists, virologists and those working on antiviral agents.
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Cover; Title Page; Copyright Page; Contents; Contributors; Preface; Chapter 1 -- Fundamentals of Viruses and Their Proteases; 1 -- Introduction; 2 -- Biochemistry of proteases; 3 -- Viruses; 3.1 -- Enveloped/Nonenveloped Viruses; 3.2 -- DNA and RNA Viruses; 4 -- Viruses containing proteases; 4.1 -- Adenoviruses; 4.1.1 -- Adenovirus Protease; 4.2 -- Alphaviruses; 4.3 -- Flaviviruses; 4.3.1 -- NS2B-NS3 Protease; 4.3.2 -- NS3 NTPase/RNA Helicase (NS3hel); 4.4 -- Hepatitis C Virus; 4.4.1 -- HCV Protease; 4.5 -- Herpes Viruses; 4.5.1 -- Herpesvirus Protease; 4.6 -- Human Immunodeficiency Virus of Type 1.

4.6.1 -- HIV1 Protease4.7 -- Picornaviruses; 4.7.1 -- Picornavirus Proteases; 5 -- Conclusions; References; Further Reading; Chapter 2 -- Design and Development of Some Viral Protease Inhibitors by QSAR and Molecular Modeling Studies; 1 -- Introduction; 2 -- Quantitative structure-activity relationship; 3 -- Viral proteases; 3.1 -- Adenoviruses; 3.1.1 -- Adenovirus Protease AVP (Adenain) Structure and Function; 3.1.2 -- Adenoviral Protease AVP (Adenain) Inhibitors; 3.2 -- Hepatitis C Virus; 3.2.1 -- NS3 Protease Structure and Function; 3.2.2 -- NS3 Protease Inhibitors; 3.3 -- Human-Immunodeficiency Virus.

3.3.1 -- HIV Protease Structure and Function3.3.2 -- HIV Protease Inhibitors; 3.4 -- Picornavirus; 3.4.1 -- Picornavirus Protease Structure and Function; 3.4.2 -- Picornavirus Protease Inhibitors; 4 -- Conclusions; References; Further reading; Chapter 3 -- Advances in Studies on Adenovirus Proteases and Their Inhibitors; 1 -- Introduction; 2 -- Adenovirus life cycle; 3 -- Adenovirus maturation protease; 4 -- Structure of AVP; 5 -- AVP inhibitors; 6 -- Conclusions; References; Chapter 4 -- Alphavirus Nonstructural Proteases and Their Inhibitors; 1 -- Introduction; 2 -- Alphaviruses; 2.1 -- Life Cycle of Virus.

2.2 -- Alphavirus and its Virion Structure3 -- Global vision of nonstructural proteins; 3.1 -- NSP1 Protease Inhibitors; 3.1.1 -- Bone Marrow Stromal Antigen-2-Based Inhibitors; 3.1.2 -- Small Hairpin RNA Molecules; 3.2 -- NSP2 Inhibitors; 3.2.1 -- Natural Inhibitors; 3.2.2 -- Druggable Targets Peptides; 3.2.3 -- NSP2-Based High-Throughput Screening; 3.2.4 -- Thienopyrrole Derivatives; 3.2.5 -- Thiazolidone Derivatives; 3.3 -- NSP3 Protease Inhibitors; 3.3.1 -- Natural Inhibitors for NSP3 Protease; 3.4 -- NSP4 Protease Inhibitors; 3.4.1 -- Nucleoside and Nonnucleoside Inhibitors.

4 -- Concluding remarks and future perspectivesAcknowledgments; References; Further Reading; Chapter 5 -- Structure and Function of Alphavirus Proteases; 1 -- Introduction; 2 -- Alphavirus proteases; 3 -- Capsid protease; 3.1 -- Proteolytic Mechanism; 3.2 -- Structure of Capsid Protease; 3.2.1 -- The Hydrophobic Pocket; 3.2.2 -- The Catalytic Triad; 3.2.3 -- The Oxyanion Hole; 3.2.4 -- Specificity Pockets; 3.3 -- trans-Protease Activity and High Throughput Inhibitor Screening Assay; 3.4 -- Capsid Protease Inhibition; 4 -- nsP2 protease; 4.1 -- Mechanism; 4.2 -- Crystal Structures of nsP2 Protease.

4.2.1 -- VEEV nsP2 Protease Structure.

Viral Proteases and Their Inhibitors provides a thorough examination of viral proteases from their molecular components, to therapeutic applications. As information on three dimensional structures and biological functions of these viral proteases become known, unexpected protein folds and unique mechanisms of proteolysis are realized. This book investigates how this facilitates the design and development of potent antiviral agents used against life-threatening viruses. Users will find descriptions of each virus that detail the structure and function of viral proteases, discuss the design and development of inhibitors, and analyze the structure-activity relationships of inhibitors. This book is ideal biochemists, virologists and those working on antiviral agents.

Includes bibliographical references and index.

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