Modeling of microscale transport in biological processes / edited by Sid M. Becker.

Print version record.

Front Cover; Modeling of Microscale Transport in Biological Processes; Copyright; Contents; Contributors; Preface; 1 Molecular Simulations of Complex Membrane Models; 1.1 Introduction; 1.1.1 Methods: Molecular Dynamics Simulations; 1.2 Unsaturated Carbon Chains; 1.3 Membrane Proteins; 1.3.1 Ion Channel Functioning; 1.3.2 Transmembrane Protein Clustering; 1.3.3 Membrane Adaptation Around Protein Clusters; 1.4 Sterols; 1.5 Eukaryotic Membranes; 1.6 Prokaryotic Membranes; 1.7 Viral Membranes; 1.8 Membrane Fusion; 1.9 Graphitic Nanomaterials; 1.10 Nanoparticles; 1.11 On-Going Work.

1.12 Outlook and Conclusion References; 2 Microbial Strategies for Oil Biodegradation; 2.1 Introduction; 2.2 Overview of the Biodegradation Process; 2.2.1 Biosurfactant-Mediated Uptake of Oil Compounds; 2.2.2 Transmembrane Transport of Oil Compounds; 2.3 Microbial Growth Modes on Oily Substrates; 2.3.1 Suspended Growth in the Aqueous Phase; 2.3.2 Flatlander's (Interfacial) Growth at the Oil-Water Interface; 2.3.3 Bio lm Growth Over the Oil-Water Interface; 2.4 Microscale Modeling Considerations; 2.5 Summary and Outlook; Acknowledgements; References.

3 Modeling and Measurement of Biomolecular Transport and Sensing in Micro uidic Cell Culture and Analysis Systems3.1 Introduction; 3.2 Basic Principles of Microscale Cell Culture; 3.3 Theory and Equations: Fluid Flow, Mass Transport, and Biochemical Reactions; 3.3.1 Fluid Motion; 3.3.2 Mass Transport in Fluids; 3.3.3 Biochemical Reactions; 3.3.4 Non-Dimensionalization; 3.4 Review of Micro uidic Transport Models; 3.4.1 Straight Microchannel with Biochemical Assay Reaction Site(s); 3.4.2 Straight Microchannel with Cell Monolayer; 3.4.3 Alternative Geometries.

3.5 Review of Theoretical Model Experimental Validation3.5.1 Experimental Validation of Micro uidic Biomolecular Transport and Sensing Models; 3.5.2 Technological Advances in Micro uidic On-Chip Analysis; 3.6 Summary and Conclusions; References; 4 Coupling Microscale Transport and Tissue Mechanics: Modeling Strategies for Arterial Multiphysics; 4.1 Introduction; 4.2 Brief on Arterial Tissues; 4.2.1 Histology and Mechanics of Arterial Tissues; 4.2.2 Molecular Transport in Arterial Tissues; 4.2.3 Extracellular Matrix Remodeling; 4.3 Arterial Multiphysics Modeling.

4.3.1 Geometric Description and General Notation4.3.2 Multiphysics Modeling Rationale; 4.3.3 Arterial Mechanical Problem; 4.3.4 Molecular Transport Problem; 4.3.5 Remodeling Laws; 4.3.6 Integrated Computational Strategy: Towards an Analytical Solution; 4.4 An Axisymmetric Case Study; 4.4.1 Arterial Geometry and Structure; 4.4.2 Quasi-Analytical Arterial Mechanics; 4.4.3 Analytical Arterial Molecular Transport; 4.4.4 Analytical Arterial Remodeling Induced by MMPs, TGF-�, and IL; 4.4.5 Results; 4.5 Conclusions; Acknowledgements; Appendix A Along-the-Chord Collagen Fiber Tangent Modulus.

Includes index.

Includes bibliographical references and index.