Chromatin regulation and dynamics / edited by Anita G�ond�or.

Includes bibliographical references and index.

Print version record.

Cover; Title page; Copyright page; Table of Contents; List of Contributors; Preface; Chapter 1 -- A Brief Introduction to Chromatin Regulation and Dynamics; 1.1 -- Introduction to Basic Concepts of Chromatin Regulation; 1.2 -- Epigenetic Phenomena: Heritability of Chromatin States During Cell Division; 1.2.1 -- Inheritance of Stable, Cell Type-Specific Gene Expression Patterns; 1.2.2 -- Genomic Imprinting; 1.2.3 -- Random Monoallelic Gene Expression; 1.2.4 -- Other Epigenetic Phenomena; 1.3 -- Reprogramming of Epigenetic States During Development and in Diseases.

1.3.1 -- Reprogramming of Epigenetic Marks During Early�Development1.3.2 -- Epigenetic Reprogramming in Tumor Development; 1.4 -- Early Period of Chromatin Research; 1.5 -- Discovery of the Nucleosome and Nucleosome Positioning; 1.6 -- Histone Modifications: Discovery and Function; 1.6.1 -- The Language of Histone Modifications; 1.7 -- Discovery of DNA Methylation: Functions and Cross Talk With Histone Modifications; 1.7.1 -- Discovery of DNA Methylation; 1.7.2 -- DNA Methylation in Tumor Development; 1.7.3 -- Cross Talk Between DNA Methylation and Histone Modifications.

1.8 -- Replication Timing: Potential Vehicle for Epigenetic Inheritance and Reprogramming1.9 -- Chromatin Folding in 3D: Basic Principles of Genome Organization; 1.9.1 -- Cross Talk Between Regulatory Elements; 1.9.2 -- Technical Innovations to Detect 3D Genome Organization; 1.9.3 -- Compartmentalization of Nuclear Functions; 1.10 -- Signal Integration at the Level of Chromatin; 1.11 -- Outlook; Abbreviations; Acknowledgments; Conflict of Interest; References; Chapter 2 -- Histone Modifications and Histone Variants in Pluripotency and Differentiation.

2.1 -- Histones and the Regulation of Transcription2.1.1 -- Histones; 2.1.1.1 -- Core and Linker Histones; 2.1.1.2 -- Histone Variants; 2.1.2 -- Histone Posttranslational Modifications; 2.1.2.1 -- Histone Acetylation; 2.1.2.2 -- Histone Methylation; 2.1.2.3 -- Context-Dependent Role of Histone Modifications; 2.1.2.4 -- Small Molecule Inhibitors of Chromatin Regulators; 2.2 -- Histone PTMs and Variants During Development; 2.2.1 -- Epigenetic Landscapes During Development; 2.2.2 -- Histone PTMs and Variants in Pluripotency and Reprogramming; 2.2.2.1 -- Unique Properties of the Chromatin of Pluripotent Cells.

2.2.2.2 -- How is a Pluripotent Epigenetic State Established?2.2.2.3 -- Histone Variants in Pluripotency; 2.2.2.4 -- Histone Modifications as Barriers Against Reprogramming; 2.2.3 -- Histone PTMs/Variants in Cell Specification and Differentiation in the Developing Central Nervous System; 2.2.3.1 -- Histone (De)Methylation in Neural Development; 2.2.3.2 -- Histone (De)Acetylation in Neural Development; 2.2.4 -- Terminally Differentiated Neural Cell States: Histones in the Regulation of Functional States; 2.2.4.1 -- Histone Modifiers in Synaptic Development.

2.2.4.2 -- Histone Modifiers in Neural Plasticity, Learning, and Memory.