Sjogren's syndrome : novel insights in pathogenic, clinical and therapeutic aspects / edited by Roberto Gerli ; co-edited by Elena Bartoloni, Alessia Alunno.

Includes bibliographical references.

Introduction : history of Sj�ogren's syndrome -- Clinical features -- Management of Sj�ogren's syndrome -- Classification criteria for Sj�ogren's syndrome -- Imaging procedures useful for the diagnosis of Sj�ogren's syndrome : abnormalities of the major salivary glands -- Sj�ogren's syndrome--associated lymphoma -- Spontaneous and inducible animal models of Sj�ogren's syndrome -- Genetics, genomics, gene expression profiling, and epigenetics in Sj�ogren's syndrome -- Autoantigens and autoantibodies in the pathogenesis of Sj�ogren's syndrome -- Sj�ogren's syndrome and environmental factors -- Histology of Sj�ogren's syndrome -- Glandular epithelium : innocent bystander or leading actor? -- T cells in the pathogenesis of Sj�ogren's syndrome : more than just Th1 and Th2 -- B lymphocytes in primary Sj�ogren's syndrome -- Cytokines, chemokines, and the innate immune system in Sj�ogren's syndrome -- Autoantibodies and autoantigens in Sj�ogren's syndrome -- Outcome measures in Sj�ogren's syndrome and perspectives in clinical trial design -- Novel therapeutic strategies in Sj�ogren's syndrome : b-cell targeting -- Novel therapeutic strategies in Sj�ogren's syndrome : t-cell targeting -- New biological avenues for Sj�ogren's syndrome.

Online resource; title from resource home page (ClinicalKey, viewed May 10, 2017).

"Sjogren's Syndrome: Novel Insights in Pathogenic, Clinical and Therapeutic Aspects provides the reader with an overview of current knowledge about Sjogren's Syndrome. The book summarizes the huge amount of literature concerning related advances in genetic background, pathogenesis, clinical picture, and therapeutic approaches. It integrates basic immunology concepts, clinical aspects, and pharmacological issues. Scientific progress has allowed us to unmask novel pathogenic mechanisms, to perform genome wide studies, and to identify clinical and serological features associated with different disease subsets and, eventually, different disease prognoses. In addition, the increasing knowledge about SS pathogenesis provides the rationale to employ targeted therapies in SS as has already occurred in rheumatoid arthritis and systemic lupus erythematosus"--Publisher's description.