Wellcome

Genomics, circuits, and pathways in clinical neuropsychiatry / edited by Thomas Lehner, Bruce L. Miller, Matthew W. State.

Contributor(s): Lehner, Thomas (Thomas A.) [editor.] | Miller, Bruce L, 1949- [editor.] | State, Matthew W [editor.]Material type: TextTextPublisher: [London, UK] : Academic Press is an imprint of Elsevier, 2016Description: 1 online resourceContent type: text Media type: computer Carrier type: online resourceISBN: 9780128005309; 0128005300Subject(s): Neuropsychiatry | HEALTH & FITNESS / Diseases / General | MEDICAL / Clinical Medicine | MEDICAL / Diseases | MEDICAL / Evidence-Based Medicine | MEDICAL / Internal Medicine | Neuropsychiatry | NeuropsychiatryGenre/Form: Electronic books.Additional physical formats: Print version:: No titleDDC classification: 616.8 LOC classification: RC341 | .G46 2016ebOnline resources: ScienceDirect
Contents:
Machine generated contents note: 1.The Newly Emerging View of the Genome -- Introduction / Christopher E. Mason / Stephan J. Sanders -- Conceptualizing DNA / Christopher E. Mason / Stephan J. Sanders -- Information Flow in Biological Systems / Christopher E. Mason / Stephan J. Sanders -- Key Definitions / Christopher E. Mason / Stephan J. Sanders -- Cis and Trans / Christopher E. Mason / Stephan J. Sanders -- Gene / Christopher E. Mason / Stephan J. Sanders -- Transcript / Christopher E. Mason / Stephan J. Sanders -- High-Throughput Sequencing / Christopher E. Mason / Stephan J. Sanders -- The Genome (DNA) / Christopher E. Mason / Stephan J. Sanders -- Visualizing the Genome / Christopher E. Mason / Stephan J. Sanders -- Large-Scale Structures in the Genome / Christopher E. Mason / Stephan J. Sanders -- Telomeres / Christopher E. Mason / Stephan J. Sanders -- Subtelomeres / Christopher E. Mason / Stephan J. Sanders -- Centromeres / Christopher E. Mason / Stephan J. Sanders
Note continued: Small-Scale Structures in the Genome / Christopher E. Mason / Stephan J. Sanders -- Protein-Coding Genes / Christopher E. Mason / Stephan J. Sanders -- Noncoding Transcripts/Genes / Christopher E. Mason / Stephan J. Sanders -- Enhancers / Christopher E. Mason / Stephan J. Sanders -- Silencers / Christopher E. Mason / Stephan J. Sanders -- Insulators / Christopher E. Mason / Stephan J. Sanders -- Repetitive Elements / Christopher E. Mason / Stephan J. Sanders -- Multiple Roles / Christopher E. Mason / Stephan J. Sanders -- Variation in the Genome / Christopher E. Mason / Stephan J. Sanders -- Entire Chromosomes / Christopher E. Mason / Stephan J. Sanders -- Structural Variation / Christopher E. Mason / Stephan J. Sanders -- Insertions and Deletions / Christopher E. Mason / Stephan J. Sanders -- Single-Nucleotide Variants / Christopher E. Mason / Stephan J. Sanders -- Loss-of-Function Variants / Christopher E. Mason / Stephan J. Sanders
Note continued: Ethnicity and Population Frequency of Variants in the Genome / Christopher E. Mason / Stephan J. Sanders -- Variation in Complex and Mendelian Disorders / Christopher E. Mason / Stephan J. Sanders -- Chromatin (DNA, RNA, and Protein) and Epigenetics / Christopher E. Mason / Stephan J. Sanders -- Chromatin State / Christopher E. Mason / Stephan J. Sanders -- Heterochromatin / Christopher E. Mason / Stephan J. Sanders -- Euchromatin / Christopher E. Mason / Stephan J. Sanders -- DNA Methylation / Christopher E. Mason / Stephan J. Sanders -- Histone Proteins / Christopher E. Mason / Stephan J. Sanders -- Chromatin Remodelers / Christopher E. Mason / Stephan J. Sanders -- Transcription Factors / Christopher E. Mason / Stephan J. Sanders -- Cofactors / Christopher E. Mason / Stephan J. Sanders -- Elongation Factors / Christopher E. Mason / Stephan J. Sanders -- Cohesins / Christopher E. Mason / Stephan J. Sanders
Note continued: Regulatory Complexes / Christopher E. Mason / Stephan J. Sanders -- Preinitiation Complex (PIC) / Stephan J. Sanders / Christopher E. Mason -- Proximal Promoter-Pausing Complexes / Christopher E. Mason / Stephan J. Sanders -- Elongation Complex / Christopher E. Mason / Stephan J. Sanders -- Transcription (RNA) / Christopher E. Mason / Stephan J. Sanders -- Posttranscriptional mRNA Modifications / Christopher E. Mason / Stephan J. Sanders -- Epitranscriptome / Christopher E. Mason / Stephan J. Sanders -- RNA Editing / Christopher E. Mason / Stephan J. Sanders -- RNA Processing / Christopher E. Mason / Stephan J. Sanders -- Translation / Christopher E. Mason / Stephan J. Sanders -- Posttranslational Modifications / Christopher E. Mason / Stephan J. Sanders -- Summary / Christopher E. Mason / Stephan J. Sanders -- References / Christopher E. Mason / Stephan J. Sanders
Note continued: 2.Contribution of Genetic Epidemiology to Our Understanding of Psychiatric Disorders / Christopher E. Mason / Stephan J. Sanders -- Introduction / Alison K. Merikangas / Kathleen R. Merikangas -- Background: Epidemiology / Alison K. Merikangas / Kathleen R. Merikangas -- Contributions to Psychiatry / Alison K. Merikangas / Kathleen R. Merikangas -- Genetic Epidemiology / Alison K. Merikangas / Kathleen R. Merikangas -- Family Studies / Alison K. Merikangas / Kathleen R. Merikangas -- Twin Studies / Alison K. Merikangas / Kathleen R. Merikangas -- Adoption Studies / Alison K. Merikangas / Kathleen R. Merikangas -- Genetic Epidemiology of Psychiatric Disorders / Alison K. Merikangas / Kathleen R. Merikangas -- Neurodevelopmental Disorders / Alison K. Merikangas / Kathleen R. Merikangas -- Eating Disorders / Alison K. Merikangas / Kathleen R. Merikangas -- Mood Disorders / Alison K. Merikangas / Kathleen R. Merikangas
Note continued: Anxiety Disorders: Panic Disorder / Alison K. Merikangas / Kathleen R. Merikangas -- Obsessive-Compulsive Disorder / Alison K. Merikangas / Kathleen R. Merikangas -- Substance Use Disorders / Alison K. Merikangas / Kathleen R. Merikangas -- Summary / Alison K. Merikangas / Kathleen R. Merikangas -- Applications of Genetic Epidemiology in Molecular Era / Alison K. Merikangas / Kathleen R. Merikangas -- Study Designs and Samples / Alison K. Merikangas / Kathleen R. Merikangas -- Statistical Approaches to Estimate Genetic Influence / Alison K. Merikangas / Kathleen R. Merikangas -- Phenotypes: Moving Beyond Dichotomous Classification / Alison K. Merikangas / Kathleen R. Merikangas -- Incorporation of Environmental Factors / Alison K. Merikangas / Kathleen R. Merikangas -- Combining Genetic and Environmental Factors / Alison K. Merikangas / Kathleen R. Merikangas -- Team Science / Alison K. Merikangas / Kathleen R. Merikangas
Note continued: References / Alison K. Merikangas / Kathleen R. Merikangas -- 3.Natural Selection and Neuropsychiatric Disease: Theory, Observation, and Emerging Genetic Findings / Alison K. Merikangas / Kathleen R. Merikangas -- Introduction / Mark J. Daly / Benjamin M. Neale / Elise B. Robinson -- Epidemiology of Neuropsychiatric Disease / Mark J. Daly / Benjamin M. Neale / Elise B. Robinson -- Theoretical Considerations / Mark J. Daly / Benjamin M. Neale / Elise B. Robinson -- Hypothesis Testing: Epidemiology and Emerging Genetic Data / Mark J. Daly / Benjamin M. Neale / Elise B. Robinson -- Mendelian Randomization and Polygenic Risk / Mark J. Daly / Benjamin M. Neale / Elise B. Robinson -- De Novo Mutation and Mutation-Selection Balance / Mark J. Daly / Benjamin M. Neale / Elise B. Robinson -- Conclusions / Mark J. Daly / Benjamin M. Neale / Elise B. Robinson -- References / Mark J. Daly / Benjamin M. Neale / Elise B. Robinson
Note continued: 4.Genome Tools and Methods: Rare Genetic Variation / Mark J. Daly / Benjamin M. Neale / Elise B. Robinson -- Rare Variants in Psychiatric Disease / Jonathan Sebat / Daniel J. Barrera -- Genetic Variation / Daniel J. Barrera / Jonathan Sebat -- Modern Technologies for Discovery of Rare Variants / Jonathan Sebat / Daniel J. Barrera -- Microarray Technology and Large-Scale Copy Number Variants in Neurodevelopmental and Neuropsychiatric Disease / Jonathan Sebat / Daniel J. Barrera -- Copy Number Variant Studies of Disease / Jonathan Sebat / Daniel J. Barrera -- Studies of De Novo Mutation in Trio Families / Jonathan Sebat / Daniel J. Barrera -- Case-Control Studies / Jonathan Sebat / Daniel J. Barrera -- Analysis Strategies / Daniel J. Barrera / Jonathan Sebat -- Genome / Daniel J. Barrera / Jonathan Sebat -- Pathways / Daniel J. Barrera / Jonathan Sebat -- Genes / Daniel J. Barrera / Jonathan Sebat -- SNVs / Daniel J. Barrera / Jonathan Sebat
Note continued: Detection of Rare Genetic Variation by High-Throughput Sequencing / Daniel J. Barrera / Jonathan Sebat -- Exome / Daniel J. Barrera / Jonathan Sebat -- Gene Panels / Daniel J. Barrera / Jonathan Sebat -- Whole Genome Sequencing / Daniel J. Barrera / Jonathan Sebat -- Rare Genetic Variation in Noncoding DNA: A New Frontier / Daniel J. Barrera / Jonathan Sebat -- Rare Genetic Variants and the Potential to Affect Clinical Care / Daniel J. Barrera / Jonathan Sebat -- References / Daniel J. Barrera / Jonathan Sebat -- 5.Neuroepigenomics and Human Disease / Daniel J. Barrera / Jonathan Sebat -- Epigenetics / John M. Greally / Eric J. Nestler -- Epigenetics in Neurobiological Research / John M. Greally / Eric J. Nestler -- The Genomic Context of Transcriptional and Epigenetic Mechanisms / John M. Greally / Eric J. Nestler -- Transcriptional and Epigenetic Regulatory Mechanisms / John M. Greally / Eric J. Nestler
Note continued: Epigenetic Perturbation and Epigenome-Wide Assays / John M. Greally / Eric J. Nestler -- Cell Type Choices in Neuroepigenomic Studies / John M. Greally / Eric J. Nestler -- Interaction of the Genome With the Epigenome / John M. Greally / Eric J. Nestler -- Epigenetics Mechanisms of Brain Diseases: General Principles and Future Directions / John M. Greally / Eric J. Nestler -- References / Eric J. Nestler / John M. Greally -- 6.Bioinformatics in Neuropsychiatric Genomics / John M. Greally / Eric J. Nestler -- What is Bioinformatics? / Shaun M. Purcell -- Databases / Shaun M. Purcell -- Methods / Shaun M. Purcell -- Tools / Shaun M. Purcell -- Standards / Shaun M. Purcell -- Summary / Shaun M. Purcell -- List of URLs / Shaun M. Purcell -- Core Genomic Databases and Portals / Shaun M. Purcell -- Genome Browsers / Shaun M. Purcell -- Genetic Variation / Shaun M. Purcell -- Gene Expression Resources / Shaun M. Purcell
Note continued: Programming Environments for Bioinformatics / Shaun M. Purcell -- Genetic Linkage, Association, and Variation Detection / Shaun M. Purcell -- Network and Pathway Analysis / Shaun M. Purcell -- Rare Variant Detection and Annotation / Shaun M. Purcell -- Identifiers, Ontologies, and Standards / Shaun M. Purcell -- Psychiatric/Neuroscience Projects / Shaun M. Purcell -- References / Shaun M. Purcell -- 7.Imaging Genomics And Enigma / Shaun M. Purcell -- Introduction / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad -- Power of MRI / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad -- What Is Imaging Genomics? / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad -- The Endophenotype Concept and Biomarkers / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad -- Mapping Brain Diseases in Neurology / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad
Note continued: MRI Versus Cellular Measures / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad -- Mapping Brain Disorders: Psychiatry / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad -- Psychiatric Neuroimaging Expands Worldwide / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad -- Meta-Analysis / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad -- ENIGMA Studies of Brain Disease / Neda Jahanshad / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein -- Defusing Controversy With Meta-Analysis / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad -- Imaging Genomics and Genome-Wide Association Studies / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad -- Genetic Influences on the Brain / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad -- Genes and Disease Risk / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad
Note continued: Manhattan Plots / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad -- Candidate Genes and Genome-Wide Association Studies / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad -- Genome-Wide Significance / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad -- Formation of ENIGMA in 2009 / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad -- Surprises From Imaging Genomics Consortia / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad -- Other Neuroimaging Methods / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad -- Multivariate Imaging Genomics and Big Data / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad -- Searching the Brain for Gene Effects / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad -- Cooperative Machine Learning / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad
Note continued: Conclusions / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad -- Acknowledgments / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad -- References / Neda Jahanshad / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein -- 8.Brain in a Dish: Stem Cell Technologies to Study Disorders of the Central Nervous System / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad -- Generating Induced Pluripotent Stem Cells / Cleber A. Trujillo / Priscilla D. Negraes / Branka Hrvoj-Mihic / Mauro F.C. Lins / Katerina Semendeferi / Alysson R. Muotri -- Progress in Modeling Human Central Nervous System Pathology: Neurodevelopmental Disorders / Cleber A. Trujillo / Priscilla D. Negraes / Branka Hrvoj-Mihic / Mauro F.C. Lins / Katerina Semendeferi / Alysson R. Muotri -- Rett Syndrome / Cleber A. Trujillo / Priscilla D. Negraes / Branka Hrvoj-Mihic / Mauro F.C. Lins / Katerina Semendeferi / Alysson R. Muotri
Note continued: Fragile X Syndrome / Cleber A. Trujillo / Priscilla D. Negraes / Branka Hrvoj-Mihic / Mauro F.C. Lins / Katerina Semendeferi / Alysson R. Muotri -- Angelman Syndrome / Cleber A. Trujillo / Priscilla D. Negraes / Branka Hrvoj-Mihic / Mauro F.C. Lins / Katerina Semendeferi / Alysson R. Muotri -- Timothy Syndrome / Cleber A. Trujillo / Priscilla D. Negraes / Branka Hrvoj-Mihic / Mauro F.C. Lins / Katerina Semendeferi / Alysson R. Muotri -- Contribution of Different Cell Types to Neurodevelopmental Disorders / Cleber A. Trujillo / Priscilla D. Negraes / Branka Hrvoj-Mihic / Mauro F.C. Lins / Katerina Semendeferi / Alysson R. Muotri -- The Next Step of Induced Pluripotent Stem Cells: Three-Dimensional Cultures and Mini-Brains / Cleber A. Trujillo / Priscilla D. Negraes / Branka Hrvoj-Mihic / Mauro F.C. Lins / Katerina Semendeferi / Alysson R. Muotri
Note continued: Limitations of Induced Pluripotent Stem Cell Model / Cleber A. Trujillo / Priscilla D. Negraes / Branka Hrvoj-Mihic / Mauro F.C. Lins / Katerina Semendeferi / Alysson R. Muotri -- Genome Editing: Creating Diseased Embryonic Stem Cells / Alysson R. Muotri / Cleber A. Trujillo / Priscilla D. Negraes / Branka Hrvoj-Mihic / Mauro F.C. Lins / Katerina Semendeferi -- Drug Discovery With Induced Pluripotent Stem Cells / Cleber A. Trujillo / Priscilla D. Negraes / Branka Hrvoj-Mihic / Mauro F.C. Lins / Katerina Semendeferi / Alysson R. Muotri -- Conclusions / Cleber A. Trujillo / Priscilla D. Negraes / Branka Hrvoj-Mihic / Mauro F.C. Lins / Katerina Semendeferi / Alysson R. Muotri -- References / Cleber A. Trujillo / Priscilla D. Negraes / Branka Hrvoj-Mihic / Mauro F.C. Lins / Katerina Semendeferi / Alysson R. Muotri
Note continued: 9.Association Strategies / Cleber A. Trujillo / Priscilla D. Negraes / Branka Hrvoj-Mihic / Mauro F.C. Lins / Katerina Semendeferi / Alysson R. Muotri -- Common Variants / Benjamin M. Neale -- Rare Variants / Benjamin M. Neale -- Conclusions / Benjamin M. Neale -- Acknowledgments / Benjamin M. Neale -- References / Benjamin M. Neale -- 10.Reconstructing Causal Network Models of Human Disease / Benjamin M. Neale -- Introduction / Eric E. Schadt -- Modeling Biological Data / Eric E. Schadt -- Causality as a Statistical Inference / Eric E. Schadt -- From Assessing Causal Relationships Among Trait Pairs to Predictive Gene Networks / Eric E. Schadt -- Building From the Bottom Up or Top Down? / Eric E. Schadt -- An Integrative Genomics Approach to Constructive Predictive Network Models / Eric E. Schadt -- Integrating Genetic Data as a Structure Before Enhancing Causal Inference in the Bayesian Network Reconstruction Process / Eric E. Schadt
Note continued: Incorporating Other -Omics Data as Network Priors in the Bayesian Network Reconstruction Process / Eric E. Schadt -- Elucidating the Complexity of Human Disease: From the Metabolic to the Psychiatric / Eric E. Schadt -- Application of Predictive Network Models to High-Throughput Screening / Eric E. Schadt -- Conclusion and Future Directions / Eric E. Schadt -- References / Eric E. Schadt -- 11.Gene Networks in Neuropsychiatric Disease / Eric E. Schadt -- Introduction / Neelroop N. Parikshak / Daniel H. Geschwind -- RNA, Protein, and Epigenetic Molecular Levels in Neurobiology / Neelroop N. Parikshak / Daniel H. Geschwind -- The Challenge of Spatial and Temporal Heterogeneity in the Central Nervous System / Neelroop N. Parikshak / Daniel H. Geschwind -- Gene Networks Provide a Framework for Neurobiological Interpretation / Neelroop N. Parikshak / Daniel H. Geschwind
Note continued: Gene Networks in Neuropsychiatric Disorders / Neelroop N. Parikshak / Daniel H. Geschwind -- Genome-Wide Approaches / Neelroop N. Parikshak / Daniel H. Geschwind -- Seed-Based Approaches / Neelroop N. Parikshak / Daniel H. Geschwind -- Protein-Protein Interaction Networks / Neelroop N. Parikshak / Daniel H. Geschwind -- Integrative Network Approaches / Neelroop N. Parikshak / Daniel H. Geschwind -- Themes From Cross-Method Comparisons / Neelroop N. Parikshak / Daniel H. Geschwind -- Conclusions and Future Directions / Neelroop N. Parikshak / Daniel H. Geschwind -- Acknowledgments / Neelroop N. Parikshak / Daniel H. Geschwind -- References / Neelroop N. Parikshak / Daniel H. Geschwind -- 12.Somatic Mosaicism and Neurological Diseases / Neelroop N. Parikshak / Daniel H. Geschwind -- Introduction / Saumya S. Jamuar / Alissa M. D'Gama / Christopher A. Walsh
Note continued: Cortical Clonal Architecture and Somatic Mutations / Saumya S. Jamuar / Alissa M. D'Gama / Christopher A. Walsh -- Somatic Mutations in Normal Brain / Saumya S. Jamuar / Alissa M. D'Gama / Christopher A. Walsh -- Somatic Mutation in Neurological Disease / Saumya S. Jamuar / Alissa M. D'Gama / Christopher A. Walsh -- "Brain-Only" Somatic Mutations / Saumya S. Jamuar / Alissa M. D'Gama / Christopher A. Walsh -- "Second-Hit" Mutations Produce Mosaicism / Saumya S. Jamuar / Alissa M. D'Gama / Christopher A. Walsh -- Neurodevelopmental Disorders Caused by Somatic Mutations / Saumya S. Jamuar / Alissa M. D'Gama / Christopher A. Walsh -- Neurological Diseases Caused or Modulated by Somatic Mutations / Saumya S. Jamuar / Alissa M. D'Gama / Christopher A. Walsh -- Types of Somatic Variants / Saumya S. Jamuar / Alissa M. D'Gama / Christopher A. Walsh -- Large-Scale Chromosomal Abnormalities / Saumya S. Jamuar / Alissa M. D'Gama / Christopher A. Walsh
Note continued: Copy Number Variants / Saumya S. Jamuar / Alissa M. D'Gama / Christopher A. Walsh -- Single-Nucleotide Variants / Saumya S. Jamuar / Alissa M. D'Gama / Christopher A. Walsh -- Tissue Type Considerations / Saumya S. Jamuar / Alissa M. D'Gama / Christopher A. Walsh -- Tools to Study Somatic Variation in the Brain / Saumya S. Jamuar / Alissa M. D'Gama / Christopher A. Walsh -- Copy Number Variants / Saumya S. Jamuar / Alissa M. D'Gama / Christopher A. Walsh -- Single-Nucleotide Variants, Including Insertions and Deletions / Saumya S. Jamuar / Alissa M. D'Gama / Christopher A. Walsh -- Conclusion / Saumya S. Jamuar / Alissa M. D'Gama / Christopher A. Walsh -- Acknowledgments / Saumya S. Jamuar / Alissa M. D'Gama / Christopher A. Walsh -- References / Saumya S. Jamuar / Alissa M. D'Gama / Christopher A. Walsh -- 13.The Molecular Landscape of the Developing Human Central Nervous System / Saumya S. Jamuar / Alissa M. D'Gama / Christopher A. Walsh
Note continued: Introduction / Nenad Sestan / Ying Zhu / John C. Silbereis / Sirisha Pochareddy / Mingfeng Li -- The Cellular and Structural Complexity of the Human Brain / John C. Silbereis / Ying Zhu / Sirisha Pochareddy / Mingfeng Li / Nenad Sestan -- General Principles of Human Neocortical Development / Ying Zhu / John C. Silbereis / Sirisha Pochareddy / Mingfeng Li / Nenad Sestan -- Neurogenesis and Neuronal Migration / John C. Silbereis / Ying Zhu / Sirisha Pochareddy / Nenad Sestan / Mingfeng Li -- Glial Cell Genesis and Differentiation / Ying Zhu / John C. Silbereis / Sirisha Pochareddy / Mingfeng Li / Nenad Sestan -- Neural Circuit Formation and Developmental Plasticity / Ying Zhu / John C. Silbereis / Mingfeng Li / Sirisha Pochareddy / Nenad Sestan -- Regional Patterning and Interhemispheric Lateralization / Ying Zhu / John C. Silbereis / Sirisha Pochareddy / Mingfeng Li / Nenad Sestan
Note continued: Transcriptional Landscape of the Developing Human Brain / Ying Zhu / John C. Silbereis / Sirisha Pochareddy / Mingfeng Li / Nenad Sestan -- Spatiotemporal Dynamics of Human Brain Transcriptome / Ying Zhu / John C. Silbereis / Sirisha Pochareddy / Mingfeng Li / Nenad Sestan -- Transcriptional Architecture Underlying Cellular and Regional Specification of the Human Brain / Ying Zhu / John C. Silbereis / Sirisha Pochareddy / Mingfeng Li / Nenad Sestan -- Transcriptional Insights Into Maturational Trajectories of the Human Neocortex / Ying Zhu / John C. Silbereis / Sirisha Pochareddy / Mingfeng Li / Nenad Sestan -- Interhemispheric Neocortical Transcriptomes / Ying Zhu / John C. Silbereis / Sirisha Pochareddy / Mingfeng Li / Nenad Sestan -- Epigenomic and Regulatory Landscapes of the Developing Human Brain / Ying Zhu / John C. Silbereis / Sirisha Pochareddy / Mingfeng Li / Nenad Sestan
Note continued: DNA Methylation in Human Brain Development / Ying Zhu / John C. Silbereis / Sirisha Pochareddy / Mingfeng Li / Nenad Sestan -- Histone Modification and Functional Regulatory Elements in Human Brain Development / Ying Zhu / John C. Silbereis / Sirisha Pochareddy / Mingfeng Li / Nenad Sestan -- Noncoding RNAs in Human Brain Development / Ying Zhu / John C. Silbereis / Sirisha Pochareddy / Mingfeng Li / Nenad Sestan -- Insights Into Psychiatric and Neurological Disorders / Ying Zhu / John C. Silbereis / Sirisha Pochareddy / Mingfeng Li / Nenad Sestan -- Conclusions and Future Directions / Ying Zhu / John C. Silbereis / Sirisha Pochareddy / Mingfeng Li / Nenad Sestan -- Acknowledgments / Ying Zhu / John C. Silbereis / Sirisha Pochareddy / Mingfeng Li / Nenad Sestan -- References / Ying Zhu / John C. Silbereis / Sirisha Pochareddy / Mingfeng Li / Nenad Sestan
Note continued: 14.Optogenetic Approaches to Neural Circuit Analysis in the Mammalian Brain / Ying Zhu / John C. Silbereis / Sirisha Pochareddy / Mingfeng Li / Nenad Sestan -- Introduction / Stephan Lammel / Gul Dolen / Robert C. Malenka -- Tools for Functional Neural Circuit Dissection / Stephan Lammel / Gul Dolen / Robert C. Malenka -- Definition of Opsins / Stephan Lammel / Gul Dolen / Robert C. Malenka -- Expression of Opsins in the Mammalian Brain / Stephan Lammel / Gul Dolen / Robert C. Malenka -- Cell Type-Specific Targeting of Opsins Using Promoters / Stephan Lammel / Gul Dolen / Robert C. Malenka -- Cell Type-Specific Targeting of Opsins Using Cre/loxP Recombinase / Stephan Lammel / Gul Dolen / Robert C. Malenka -- Intersectional Approaches / Stephan Lammel / Gul Dolen / Robert C. Malenka -- Functional Circuit Analysis / Stephan Lammel / Gul Dolen / Robert C. Malenka
Note continued: Ex Vivo Synaptic Input Specificity / Stephan Lammel / Gul Dolen / Robert C. Malenka -- In Vivo Neural Circuit Analysis in Freely Moving Animals / Stephan Lammel / Gul Dolen / Robert C. Malenka -- Translational Medicine / Stephan Lammel / Gul Dolen / Robert C. Malenka -- Conclusions / Stephan Lammel / Gul Dolen / Robert C. Malenka -- References / Stephan Lammel / Gul Dolen / Robert C. Malenka -- 15.Brain Imaging With Magneto-encephalography During Rest and During Speech and Language Processing / Stephan Lammel / Gul Dolen / Robert C. Malenka -- Brain Imaging With Magnetoencephalography (MEG) / Srikantan S. Nagarajan / Kamalini G. Ranasinghe / Keith A. Vossel -- Sensing the Brain's Magnetic Fields / Srikantan S. Nagarajan / Kamalini G. Ranasinghe / Keith A. Vossel -- From Sensing to Imaging / Srikantan S. Nagarajan / Kamalini G. Ranasinghe / Keith A. Vossel
Note continued: Forward Models Describing Brain Activity and Measurements / Srikantan S. Nagarajan / Kamalini G. Ranasinghe / Keith A. Vossel -- Inverse Models for Reconstructing Brain Activity From Measurements / Srikantan S. Nagarajan / Kamalini G. Ranasinghe / Keith A. Vossel -- Sources of Noise in Magnetoencephalography / Srikantan S. Nagarajan / Kamalini G. Ranasinghe / Keith A. Vossel -- Temporal and Spatial Resolution of Magnetoencephalography Imaging / Srikantan S. Nagarajan / Kamalini G. Ranasinghe / Keith A. Vossel -- From Single-Subject Reconstructions to Group-Level Inference / Srikantan S. Nagarajan / Kamalini G. Ranasinghe / Keith A. Vossel -- Magnetoencephalography Studies in Aging and Dementia / Srikantan S. Nagarajan / Kamalini G. Ranasinghe / Keith A. Vossel -- Resting Magnetoencephalography Studies in Aging and Dementia / Srikantan S. Nagarajan / Kamalini G. Ranasinghe / Keith A. Vossel
Note continued: Activation Magnetoencephalography Studies in Aging and Dementia / Srikantan S. Nagarajan / Kamalini G. Ranasinghe / Keith A. Vossel -- Summary and Conclusions / Srikantan S. Nagarajan / Kamalini G. Ranasinghe / Keith A. Vossel -- References / Srikantan S. Nagarajan / Kamalini G. Ranasinghe / Keith A. Vossel -- 16.Resting-State Functional MRI: A Novel Tool for Understanding Brain Networks in Neuropsychiatric Disorders / Srikantan S. Nagarajan / Kamalini G. Ranasinghe / Keith A. Vossel -- A Brief History of Resting-State Functional MRI / Michael Greicius -- Healthy Skepticism Drives Deeper Explorations / Michael Greicius -- Attributes of Resting-State Networks / Michael Greicius -- Default-Mode and Salience Networks / Michael Greicius -- Applications to Brain Disease / Michael Greicius -- Future Directions / Michael Greicius -- References / Michael Greicius -- 17.Neuroimaging Advances in Alzheimer's Disease / Michael Greicius
Note continued: Abbreviations / Daniel R. Schonhaut / Gil D. Rabinovici -- Introduction / Daniel R. Schonhaut / Gil D. Rabinovici -- Alzheimer's Disease Defined / Daniel R. Schonhaut / Gil D. Rabinovici -- Imaging Characteristics of Alzheimer's Disease / Daniel R. Schonhaut / Gil D. Rabinovici -- Structural MRI / Daniel R. Schonhaut / Gil D. Rabinovici -- Functional MRI / Daniel R. Schonhaut / Gil D. Rabinovici -- [18F]Fluoro-2-Deoxy-o-Glucose Positron Emission Tomography / Daniel R. Schonhaut / Gil D. Rabinovici -- Amyloid Positron Emission Tomography / Daniel R. Schonhaut / Gil D. Rabinovici -- Tau Positron Emission Tomography / Daniel R. Schonhaut / Gil D. Rabinovici -- Progression of Neuroimaging Abnormalities: An Amyloid Cascade? / Daniel R. Schonhaut / Gil D. Rabinovici -- Preclinical Alzheimer's Disease / Daniel R. Schonhaut / Gil D. Rabinovici -- Mild Cognitive Impairment / Daniel R. Schonhaut / Gil D. Rabinovici
Note continued: Dementia and Limitations of the Amyloid Cascade Hypothesis / Daniel R. Schonhaut / Gil D. Rabinovici -- Underlying Mechanisms of Alzheimer's Disease Pathology / Daniel R. Schonhaut / Gil D. Rabinovici -- Amyloid Plaques Form in Regional Hubs / Daniel R. Schonhaut / Gil D. Rabinovici -- Tau Spreads Through Functional Networks / Daniel R. Schonhaut / Gil D. Rabinovici -- Conclusions / Daniel R. Schonhaut / Gil D. Rabinovici -- References / Daniel R. Schonhaut / Gil D. Rabinovici -- 18.Progressive Supranuclear Palsy and Related Parkinsonian Disorders / Daniel R. Schonhaut / Gil D. Rabinovici -- Introduction / Jesse A. Brown / William W. Seeley -- Each Neurodegenerative Syndrome Reflects a Network / Jesse A. Brown / William W. Seeley -- Class-Wide Principles of Network-Based Neurodegeneration / Jesse A. Brown / William W. Seeley -- Parkinsonian Syndromes: Parkinson Disease and Others / Jesse A. Brown / William W. Seeley
Note continued: Parkinson Disease: Clinical and Anatomical Features / Jesse A. Brown / William W. Seeley -- Progressive Supranuclear Palsy Syndrome: Clinical Features / Jesse A. Brown / William W. Seeley -- Corticobasal Syndrome: Clinical Features / Jesse A. Brown / William W. Seeley -- Network Architecture of Neurodegenerative Parkinsonian Syndromes / William W. Seeley / Jesse A. Brown -- Network Architecture of Progressive Supranuclear Palsy Syndrome / Jesse A. Brown / William W. Seeley -- Network Architecture of Corticobasal Syndrome / Jesse A. Brown / William W. Seeley -- Clinicopathological Correlation in Progressive Supranuclear Palsy and Corticobasal Degeneration / Jesse A. Brown / William W. Seeley -- Multiple Proteinopathies Can Cause Progressive Supranuclear Palsy Syndrome and Corticobasal Syndrome / Jesse A. Brown / William W. Seeley -- Pathological Causes of Progressive Supranuclear Palsy Syndrome / Jesse A. Brown / William W. Seeley
Note continued: Pathological Causes of Corticobasal Syndrome / Jesse A. Brown / William W. Seeley -- Progressive Supranuclear Palsy and Corticobasal Degeneration Histopathology Can Cause Multiple Clinical Syndromes / Jesse A. Brown / William W. Seeley -- Genetic Factors in Progressive Supranuclear Palsy and Corticobasal Degeneration / Jesse A. Brown / William W. Seeley -- Rare Monogenic Causes / Jesse A. Brown / William W. Seeley -- Risk Factors / Jesse A. Brown / William W. Seeley -- Genome-Wide Association Studies / Jesse A. Brown / William W. Seeley -- Conclusion / Jesse A. Brown / William W. Seeley -- Acknowledgment / Jesse A. Brown / William W. Seeley -- References / Jesse A. Brown / William W. Seeley -- 19.A New Neuroanatomy of Basal Ganglia Circuitry / Jesse A. Brown / William W. Seeley -- Abbreviations / Nicholas AuYong / Adrienne M. Keener / Yvette M. Bordelon / Carlos Portera-Cailliau / Nader Pouratian
Note continued: Anatomic Overview of Basal Ganglia / Nicholas AuYong / Adrienne M. Keener / Yvette M. Bordelon / Carlos Portera-Cailliau / Nader Pouratian -- Clinical Basal Ganglia Disorders / Nicholas AuYong / Adrienne M. Keener / Yvette M. Bordelon / Carlos Portera-Cailliau / Nader Pouratian -- Parkinson Disease / Nicholas AuYong / Adrienne M. Keener / Yvette M. Bordelon / Carlos Portera-Cailliau / Nader Pouratian -- Huntington Disease / Nicholas AuYong / Adrienne M. Keener / Yvette M. Bordelon / Carlos Portera-Cailliau / Nader Pouratian -- Classical Basal Ganglia Microanatomy / Nicholas AuYong / Adrienne M. Keener / Yvette M. Bordelon / Carlos Portera-Cailliau / Nader Pouratian -- Probing Basal Ganglia Circuitry in Animal Models / Carlos Portera-Cailliau / Nader Pouratian / Nicholas AuYong / Adrienne M. Keener / Yvette M. Bordelon -- Recordings in Animals / Nicholas AuYong / Adrienne M. Keener / Yvette M. Bordelon / Carlos Portera-Cailliau / Nader Pouratian
Note continued: Ablation Studies / Nicholas AuYong / Adrienne M. Keener / Yvette M. Bordelon / Carlos Portera-Cailliau / Nader Pouratian -- Optogenetics / Nicholas AuYong / Adrienne M. Keener / Yvette M. Bordelon / Carlos Portera-Cailliau / Nader Pouratian -- Animal Studies Reveal Flaws in the Classical Model of Basal Ganglia Circuitry / Nicholas AuYong / Adrienne M. Keener / Yvette M. Bordelon / Carlos Portera-Cailliau / Nader Pouratian -- Emerging Techniques to Study Basal Ganglia Circuitry in Animals / Nicholas AuYong / Adrienne M. Keener / Yvette M. Bordelon / Carlos Portera-Cailliau / Nader Pouratian -- Calcium Imaging / Nicholas AuYong / Adrienne M. Keener / Yvette M. Bordelon / Carlos Portera-Cailliau / Nader Pouratian -- Voltage Sensors / Nicholas AuYong / Adrienne M. Keener / Yvette M. Bordelon / Carlos Portera-Cailliau / Nader Pouratian -- Optogenetics / Nicholas AuYong / Adrienne M. Keener / Yvette M. Bordelon / Carlos Portera-Cailliau / Nader Pouratian
Note continued: Striatal Interneurons / Nicholas AuYong / Adrienne M. Keener / Yvette M. Bordelon / Carlos Portera-Cailliau / Nader Pouratian -- Probing Basal Ganglia Circuitry in Humans: Invasive Physiology / Nicholas AuYong / Adrienne M. Keener / Yvette M. Bordelon / Carlos Portera-Cailliau / Nader Pouratian -- Noninvasive Studies of Basal Ganglia Circuitry in Humans / Nicholas AuYong / Adrienne M. Keener / Yvette M. Bordelon / Carlos Portera-Cailliau / Nader Pouratian -- Conclusions / Nicholas AuYong / Adrienne M. Keener / Yvette M. Bordelon / Carlos Portera-Cailliau / Nader Pouratian -- References / Yvette M. Bordelon / Carlos Portera-Cailliau / Nader Pouratian / Nicholas AuYong / Adrienne M. Keener -- 20.Brainstem Circuitry and Emotions / Nicholas AuYong / Adrienne M. Keener / Yvette M. Bordelon / Carlos Portera-Cailliau / Nader Pouratian -- The Structural Organization of the Brainstem / Panos Theofilas / Helmut Heinsen / Lea T. Grinberg
Note continued: Reticular Formation / Panos Theofilas / Helmut Heinsen / Lea T. Grinberg -- Chemical Properties of the Reticular Nuclei / Panos Theofilas / Helmut Heinsen / Lea T. Grinberg -- Reticular Formation Modulates Behavior / Panos Theofilas / Helmut Heinsen / Lea T. Grinberg -- Sleep Cycle / Panos Theofilas / Helmut Heinsen / Lea T. Grinberg -- Mood / Panos Theofilas / Helmut Heinsen / Lea T. Grinberg -- Conclusion / Panos Theofilas / Helmut Heinsen / Lea T. Grinberg -- References / Panos Theofilas / Helmut Heinsen / Lea T. Grinberg -- 21.Apathy: Frontal and Basal Ganglia Circuits / Panos Theofilas / Helmut Heinsen / Lea T. Grinberg -- Introduction / Pongsatorn Paholpak / Mario F. Mendez -- Definition and Diagnosis of Apathy / Pongsatorn Paholpak / Mario F. Mendez -- Clinical Variants, Diagnosis, and Measurement of Apathy / Pongsatorn Paholpak / Mario F. Mendez -- Measurement and Rating Scale / Pongsatorn Paholpak / Mario F. Mendez
Note continued: Molecular and Neuroanatomical Basis of Apathy / Pongsatorn Paholpak / Mario F. Mendez -- Prefrontal Cortex in Primates / Pongsatorn Paholpak / Mario F. Mendez -- Prefrontal Cortex in Humans / Pongsatorn Paholpak / Mario F. Mendez -- Motivation and Reward System: Basal Ganglia Structures and Corticostriatal Loop / Pongsatorn Paholpak / Mario F. Mendez -- Structural and Functional Connectivity in Apathy / Pongsatorn Paholpak / Mario F. Mendez -- Dopamine Regulation in Motivation and Reward System / Pongsatorn Paholpak / Mario F. Mendez -- Apathy in Neuropsychiatric Diseases / Pongsatorn Paholpak / Mario F. Mendez -- Traumatic Brain Injury / Pongsatorn Paholpak / Mario F. Mendez -- Schizophrenia / Pongsatorn Paholpak / Mario F. Mendez -- Stroke / Pongsatorn Paholpak / Mario F. Mendez -- Parkinson Disease / Mario F. Mendez / Pongsatorn Paholpak -- Huntington Disease / Pongsatorn Paholpak / Mario F. Mendez
Note continued: Alzheimer Dementia / Pongsatorn Paholpak / Mario F. Mendez -- Frontotemporal Dementia / Pongsatorn Paholpak / Mario F. Mendez -- Genetics Studies of Apathy / Pongsatorn Paholpak / Mario F. Mendez -- Huntington Disease / Pongsatorn Paholpak / Mario F. Mendez -- Parkinson Disease and Parkinsonism / Pongsatorn Paholpak / Mario F. Mendez -- Alzheimer Dementia / Pongsatorn Paholpak / Mario F. Mendez -- Frontotemporal Dementia / Pongsatorn Paholpak / Mario F. Mendez -- Schizophrenia / Pongsatorn Paholpak / Mario F. Mendez -- Summary / Pongsatorn Paholpak / Mario F. Mendez -- References / Pongsatorn Paholpak / Mario F. Mendez -- 22.Emotional Dysfunction in Psychopathology and Neuropathology: Neural and Genetic Pathways / Pongsatorn Paholpak / Mario F. Mendez -- Emotional Dysfunction in Psychopathology and Neuropathology: Neural and Genetic Pathways / Virginia E. Sturm / Claudia M. Haase / Robert W. Levenson
Note continued: Emotions and Emotional Processes Emotions: Short and Discrete / Virginia E. Sturm / Claudia M. Haase / Robert W. Levenson -- Emotional Processes / Virginia E. Sturm / Claudia M. Haase / Robert W. Levenson -- Emotional Reactivity / Virginia E. Sturm / Claudia M. Haase / Robert W. Levenson -- Emotional Regulation / Virginia E. Sturm / Claudia M. Haase / Robert W. Levenson -- Emotional Affiliation / Virginia E. Sturm / Claudia M. Haase / Robert W. Levenson -- Emotional Functioning: Neural Pathways / Virginia E. Sturm / Claudia M. Haase / Robert W. Levenson -- Emotional Reactivity / Virginia E. Sturm / Claudia M. Haase / Robert W. Levenson -- Anterior Cingulate Cortex / Virginia E. Sturm / Claudia M. Haase / Robert W. Levenson -- Amygdala / Virginia E. Sturm / Claudia M. Haase / Robert W. Levenson -- Hypothalamus / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Brain Stem / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase
Note continued: Insula / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Emotion Regulation / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Ventrolateral Prefrontal Cortex / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Dorsolateral Prefrontal Cortex / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Anterior Midcingulate Cortex / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Inferior Parietal Lobe / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Emotional Affiliation / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Superior Temporal Sulcus / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Dorsomedial Prefrontal Cortex / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Ventral Striatum / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Medial Orbitofrontal Cortex / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase
Note continued: Septal Area / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Emotion Functioning: Genetic Pathways / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Model of the Genetic Pathway / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Emotional Reactivity / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Serotonin-Related Genes / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Other Genes / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Emotion Regulation / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Dopamine-Related Genes / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Other Genes / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Emotional Affiliation / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Oxytocin-Related Genes / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase
Note continued: Other Genes and Affiliation / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Neural and Genetic Pathways: Clinical Implications / Virginia E. Sturm / Claudia M. Haase / Robert W. Levenson -- Emotional Dysfunction in Psychopathology and Neuropathology / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Emotional Reactivity / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Emotion Regulation / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Emotional Affiliation / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Emotion in Diagnosis / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Psychopathology: Diagnostic and Statistical Manual / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Psychopathology: Research Domain Criteria / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Neuropathology / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase
Note continued: Emotion in Treatment / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- References / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- 23.The Anatomy of Delusion / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Introduction and Definition / Georges Naasan -- Phenomenology and Anatomy / Georges Naasan -- The Two-Factor Hypothesis and the Role of the Right Prefrontal Cortex / Georges Naasan -- Attention Bias and Faulty Assignment of Salience to External Stimuli: The "Aberrant Salience" Model / Georges Naasan -- The Theory of Mind in People With Delusions / Georges Naasan -- Content-Specific Delusions / Georges Naasan -- Paranoid Delusions / Georges Naasan -- The Capgras Delusion / Georges Naasan -- Genetics / Georges Naasan -- References / Georges Naasan -- 24.Beyond Dopamine: The Role of the Serotonergic System and Treatments in Understanding and Treating Visual Hallucinations in Parkinson Disease / Georges Naasan
Note continued: Simple Versus Complex Visual Hallucinations / Andrew Evans / Ramon Mocellin / Dennis Velakoulis / Mark Walterfang -- The Visual Pathway and Mechanisms of Disruption Leading to Visual Hallucinations / Dennis Velakoulis / Mark Walterfang / Andrew Evans / Ramon Mocellin -- Complex Visual Hallucinations: The Role of Lesion Location / Dennis Velakoulis / Mark Walterfang / Andrew Evans / Ramon Mocellin -- Synucleinopathy and Visual Hallucinations / Dennis Velakoulis / Mark Walterfang / Andrew Evans / Ramon Mocellin -- The Origins of Visual Hallucinations in Parkinson Disease / Dennis Velakoulis / Mark Walterfang / Andrew Evans / Ramon Mocellin -- The Serotonergic System and Visual Hallucinations / Dennis Velakoulis / Mark Walterfang / Andrew Evans / Ramon Mocellin -- Anatomy of the Serotonergic System / Dennis Velakoulis / Mark Walterfang / Andrew Evans / Ramon Mocellin
Note continued: Psilocybin and the Serotonergic System / Dennis Velakoulis / Mark Walterfang / Andrew Evans / Ramon Mocellin -- Parkinson Disease and the Serotonergic System / Dennis Velakoulis / Mark Walterfang / Andrew Evans / Ramon Mocellin -- Pharmacological Interventions for Visual Hallucinations in Parkinson Disease / Dennis Velakoulis / Mark Walterfang / Andrew Evans / Ramon Mocellin -- D2 Antagonism / Dennis Velakoulis / Mark Walterfang / Andrew Evans / Ramon Mocellin -- Serotonin Antagonism / Dennis Velakoulis / Mark Walterfang / Andrew Evans / Ramon Mocellin -- Summary / Dennis Velakoulis / Mark Walterfang / Andrew Evans / Ramon Mocellin -- References / Dennis Velakoulis / Mark Walterfang / Andrew Evans / Ramon Mocellin -- 25.Risk Overlap Between Clinical Disorders / Dennis Velakoulis / Mark Walterfang / Andrew Evans / Ramon Mocellin -- Introduction / Patrick F. Sullivan -- Clinical Neuroscience, Neurology, and Psychiatry / Patrick F. Sullivan
Item type:
Tags from this library: No tags from this library for this title. Log in to add tags.
Holdings
Item type Current library Call number Status Date due Barcode
Ebooks Ebooks Mysore University Main Library
Not for loan EBKELV283

Includes index.

Online resource; title from PDF title page (ScienceDirect, viewed July 13, 2016).

Machine generated contents note: 1.The Newly Emerging View of the Genome -- Introduction / Christopher E. Mason / Stephan J. Sanders -- Conceptualizing DNA / Christopher E. Mason / Stephan J. Sanders -- Information Flow in Biological Systems / Christopher E. Mason / Stephan J. Sanders -- Key Definitions / Christopher E. Mason / Stephan J. Sanders -- Cis and Trans / Christopher E. Mason / Stephan J. Sanders -- Gene / Christopher E. Mason / Stephan J. Sanders -- Transcript / Christopher E. Mason / Stephan J. Sanders -- High-Throughput Sequencing / Christopher E. Mason / Stephan J. Sanders -- The Genome (DNA) / Christopher E. Mason / Stephan J. Sanders -- Visualizing the Genome / Christopher E. Mason / Stephan J. Sanders -- Large-Scale Structures in the Genome / Christopher E. Mason / Stephan J. Sanders -- Telomeres / Christopher E. Mason / Stephan J. Sanders -- Subtelomeres / Christopher E. Mason / Stephan J. Sanders -- Centromeres / Christopher E. Mason / Stephan J. Sanders

Note continued: Small-Scale Structures in the Genome / Christopher E. Mason / Stephan J. Sanders -- Protein-Coding Genes / Christopher E. Mason / Stephan J. Sanders -- Noncoding Transcripts/Genes / Christopher E. Mason / Stephan J. Sanders -- Enhancers / Christopher E. Mason / Stephan J. Sanders -- Silencers / Christopher E. Mason / Stephan J. Sanders -- Insulators / Christopher E. Mason / Stephan J. Sanders -- Repetitive Elements / Christopher E. Mason / Stephan J. Sanders -- Multiple Roles / Christopher E. Mason / Stephan J. Sanders -- Variation in the Genome / Christopher E. Mason / Stephan J. Sanders -- Entire Chromosomes / Christopher E. Mason / Stephan J. Sanders -- Structural Variation / Christopher E. Mason / Stephan J. Sanders -- Insertions and Deletions / Christopher E. Mason / Stephan J. Sanders -- Single-Nucleotide Variants / Christopher E. Mason / Stephan J. Sanders -- Loss-of-Function Variants / Christopher E. Mason / Stephan J. Sanders

Note continued: Ethnicity and Population Frequency of Variants in the Genome / Christopher E. Mason / Stephan J. Sanders -- Variation in Complex and Mendelian Disorders / Christopher E. Mason / Stephan J. Sanders -- Chromatin (DNA, RNA, and Protein) and Epigenetics / Christopher E. Mason / Stephan J. Sanders -- Chromatin State / Christopher E. Mason / Stephan J. Sanders -- Heterochromatin / Christopher E. Mason / Stephan J. Sanders -- Euchromatin / Christopher E. Mason / Stephan J. Sanders -- DNA Methylation / Christopher E. Mason / Stephan J. Sanders -- Histone Proteins / Christopher E. Mason / Stephan J. Sanders -- Chromatin Remodelers / Christopher E. Mason / Stephan J. Sanders -- Transcription Factors / Christopher E. Mason / Stephan J. Sanders -- Cofactors / Christopher E. Mason / Stephan J. Sanders -- Elongation Factors / Christopher E. Mason / Stephan J. Sanders -- Cohesins / Christopher E. Mason / Stephan J. Sanders

Note continued: Regulatory Complexes / Christopher E. Mason / Stephan J. Sanders -- Preinitiation Complex (PIC) / Stephan J. Sanders / Christopher E. Mason -- Proximal Promoter-Pausing Complexes / Christopher E. Mason / Stephan J. Sanders -- Elongation Complex / Christopher E. Mason / Stephan J. Sanders -- Transcription (RNA) / Christopher E. Mason / Stephan J. Sanders -- Posttranscriptional mRNA Modifications / Christopher E. Mason / Stephan J. Sanders -- Epitranscriptome / Christopher E. Mason / Stephan J. Sanders -- RNA Editing / Christopher E. Mason / Stephan J. Sanders -- RNA Processing / Christopher E. Mason / Stephan J. Sanders -- Translation / Christopher E. Mason / Stephan J. Sanders -- Posttranslational Modifications / Christopher E. Mason / Stephan J. Sanders -- Summary / Christopher E. Mason / Stephan J. Sanders -- References / Christopher E. Mason / Stephan J. Sanders

Note continued: 2.Contribution of Genetic Epidemiology to Our Understanding of Psychiatric Disorders / Christopher E. Mason / Stephan J. Sanders -- Introduction / Alison K. Merikangas / Kathleen R. Merikangas -- Background: Epidemiology / Alison K. Merikangas / Kathleen R. Merikangas -- Contributions to Psychiatry / Alison K. Merikangas / Kathleen R. Merikangas -- Genetic Epidemiology / Alison K. Merikangas / Kathleen R. Merikangas -- Family Studies / Alison K. Merikangas / Kathleen R. Merikangas -- Twin Studies / Alison K. Merikangas / Kathleen R. Merikangas -- Adoption Studies / Alison K. Merikangas / Kathleen R. Merikangas -- Genetic Epidemiology of Psychiatric Disorders / Alison K. Merikangas / Kathleen R. Merikangas -- Neurodevelopmental Disorders / Alison K. Merikangas / Kathleen R. Merikangas -- Eating Disorders / Alison K. Merikangas / Kathleen R. Merikangas -- Mood Disorders / Alison K. Merikangas / Kathleen R. Merikangas

Note continued: Anxiety Disorders: Panic Disorder / Alison K. Merikangas / Kathleen R. Merikangas -- Obsessive-Compulsive Disorder / Alison K. Merikangas / Kathleen R. Merikangas -- Substance Use Disorders / Alison K. Merikangas / Kathleen R. Merikangas -- Summary / Alison K. Merikangas / Kathleen R. Merikangas -- Applications of Genetic Epidemiology in Molecular Era / Alison K. Merikangas / Kathleen R. Merikangas -- Study Designs and Samples / Alison K. Merikangas / Kathleen R. Merikangas -- Statistical Approaches to Estimate Genetic Influence / Alison K. Merikangas / Kathleen R. Merikangas -- Phenotypes: Moving Beyond Dichotomous Classification / Alison K. Merikangas / Kathleen R. Merikangas -- Incorporation of Environmental Factors / Alison K. Merikangas / Kathleen R. Merikangas -- Combining Genetic and Environmental Factors / Alison K. Merikangas / Kathleen R. Merikangas -- Team Science / Alison K. Merikangas / Kathleen R. Merikangas

Note continued: References / Alison K. Merikangas / Kathleen R. Merikangas -- 3.Natural Selection and Neuropsychiatric Disease: Theory, Observation, and Emerging Genetic Findings / Alison K. Merikangas / Kathleen R. Merikangas -- Introduction / Mark J. Daly / Benjamin M. Neale / Elise B. Robinson -- Epidemiology of Neuropsychiatric Disease / Mark J. Daly / Benjamin M. Neale / Elise B. Robinson -- Theoretical Considerations / Mark J. Daly / Benjamin M. Neale / Elise B. Robinson -- Hypothesis Testing: Epidemiology and Emerging Genetic Data / Mark J. Daly / Benjamin M. Neale / Elise B. Robinson -- Mendelian Randomization and Polygenic Risk / Mark J. Daly / Benjamin M. Neale / Elise B. Robinson -- De Novo Mutation and Mutation-Selection Balance / Mark J. Daly / Benjamin M. Neale / Elise B. Robinson -- Conclusions / Mark J. Daly / Benjamin M. Neale / Elise B. Robinson -- References / Mark J. Daly / Benjamin M. Neale / Elise B. Robinson

Note continued: 4.Genome Tools and Methods: Rare Genetic Variation / Mark J. Daly / Benjamin M. Neale / Elise B. Robinson -- Rare Variants in Psychiatric Disease / Jonathan Sebat / Daniel J. Barrera -- Genetic Variation / Daniel J. Barrera / Jonathan Sebat -- Modern Technologies for Discovery of Rare Variants / Jonathan Sebat / Daniel J. Barrera -- Microarray Technology and Large-Scale Copy Number Variants in Neurodevelopmental and Neuropsychiatric Disease / Jonathan Sebat / Daniel J. Barrera -- Copy Number Variant Studies of Disease / Jonathan Sebat / Daniel J. Barrera -- Studies of De Novo Mutation in Trio Families / Jonathan Sebat / Daniel J. Barrera -- Case-Control Studies / Jonathan Sebat / Daniel J. Barrera -- Analysis Strategies / Daniel J. Barrera / Jonathan Sebat -- Genome / Daniel J. Barrera / Jonathan Sebat -- Pathways / Daniel J. Barrera / Jonathan Sebat -- Genes / Daniel J. Barrera / Jonathan Sebat -- SNVs / Daniel J. Barrera / Jonathan Sebat

Note continued: Detection of Rare Genetic Variation by High-Throughput Sequencing / Daniel J. Barrera / Jonathan Sebat -- Exome / Daniel J. Barrera / Jonathan Sebat -- Gene Panels / Daniel J. Barrera / Jonathan Sebat -- Whole Genome Sequencing / Daniel J. Barrera / Jonathan Sebat -- Rare Genetic Variation in Noncoding DNA: A New Frontier / Daniel J. Barrera / Jonathan Sebat -- Rare Genetic Variants and the Potential to Affect Clinical Care / Daniel J. Barrera / Jonathan Sebat -- References / Daniel J. Barrera / Jonathan Sebat -- 5.Neuroepigenomics and Human Disease / Daniel J. Barrera / Jonathan Sebat -- Epigenetics / John M. Greally / Eric J. Nestler -- Epigenetics in Neurobiological Research / John M. Greally / Eric J. Nestler -- The Genomic Context of Transcriptional and Epigenetic Mechanisms / John M. Greally / Eric J. Nestler -- Transcriptional and Epigenetic Regulatory Mechanisms / John M. Greally / Eric J. Nestler

Note continued: Epigenetic Perturbation and Epigenome-Wide Assays / John M. Greally / Eric J. Nestler -- Cell Type Choices in Neuroepigenomic Studies / John M. Greally / Eric J. Nestler -- Interaction of the Genome With the Epigenome / John M. Greally / Eric J. Nestler -- Epigenetics Mechanisms of Brain Diseases: General Principles and Future Directions / John M. Greally / Eric J. Nestler -- References / Eric J. Nestler / John M. Greally -- 6.Bioinformatics in Neuropsychiatric Genomics / John M. Greally / Eric J. Nestler -- What is Bioinformatics? / Shaun M. Purcell -- Databases / Shaun M. Purcell -- Methods / Shaun M. Purcell -- Tools / Shaun M. Purcell -- Standards / Shaun M. Purcell -- Summary / Shaun M. Purcell -- List of URLs / Shaun M. Purcell -- Core Genomic Databases and Portals / Shaun M. Purcell -- Genome Browsers / Shaun M. Purcell -- Genetic Variation / Shaun M. Purcell -- Gene Expression Resources / Shaun M. Purcell

Note continued: Programming Environments for Bioinformatics / Shaun M. Purcell -- Genetic Linkage, Association, and Variation Detection / Shaun M. Purcell -- Network and Pathway Analysis / Shaun M. Purcell -- Rare Variant Detection and Annotation / Shaun M. Purcell -- Identifiers, Ontologies, and Standards / Shaun M. Purcell -- Psychiatric/Neuroscience Projects / Shaun M. Purcell -- References / Shaun M. Purcell -- 7.Imaging Genomics And Enigma / Shaun M. Purcell -- Introduction / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad -- Power of MRI / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad -- What Is Imaging Genomics? / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad -- The Endophenotype Concept and Biomarkers / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad -- Mapping Brain Diseases in Neurology / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad

Note continued: MRI Versus Cellular Measures / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad -- Mapping Brain Disorders: Psychiatry / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad -- Psychiatric Neuroimaging Expands Worldwide / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad -- Meta-Analysis / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad -- ENIGMA Studies of Brain Disease / Neda Jahanshad / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein -- Defusing Controversy With Meta-Analysis / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad -- Imaging Genomics and Genome-Wide Association Studies / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad -- Genetic Influences on the Brain / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad -- Genes and Disease Risk / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad

Note continued: Manhattan Plots / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad -- Candidate Genes and Genome-Wide Association Studies / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad -- Genome-Wide Significance / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad -- Formation of ENIGMA in 2009 / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad -- Surprises From Imaging Genomics Consortia / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad -- Other Neuroimaging Methods / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad -- Multivariate Imaging Genomics and Big Data / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad -- Searching the Brain for Gene Effects / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad -- Cooperative Machine Learning / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad

Note continued: Conclusions / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad -- Acknowledgments / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad -- References / Neda Jahanshad / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein -- 8.Brain in a Dish: Stem Cell Technologies to Study Disorders of the Central Nervous System / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad -- Generating Induced Pluripotent Stem Cells / Cleber A. Trujillo / Priscilla D. Negraes / Branka Hrvoj-Mihic / Mauro F.C. Lins / Katerina Semendeferi / Alysson R. Muotri -- Progress in Modeling Human Central Nervous System Pathology: Neurodevelopmental Disorders / Cleber A. Trujillo / Priscilla D. Negraes / Branka Hrvoj-Mihic / Mauro F.C. Lins / Katerina Semendeferi / Alysson R. Muotri -- Rett Syndrome / Cleber A. Trujillo / Priscilla D. Negraes / Branka Hrvoj-Mihic / Mauro F.C. Lins / Katerina Semendeferi / Alysson R. Muotri

Note continued: Fragile X Syndrome / Cleber A. Trujillo / Priscilla D. Negraes / Branka Hrvoj-Mihic / Mauro F.C. Lins / Katerina Semendeferi / Alysson R. Muotri -- Angelman Syndrome / Cleber A. Trujillo / Priscilla D. Negraes / Branka Hrvoj-Mihic / Mauro F.C. Lins / Katerina Semendeferi / Alysson R. Muotri -- Timothy Syndrome / Cleber A. Trujillo / Priscilla D. Negraes / Branka Hrvoj-Mihic / Mauro F.C. Lins / Katerina Semendeferi / Alysson R. Muotri -- Contribution of Different Cell Types to Neurodevelopmental Disorders / Cleber A. Trujillo / Priscilla D. Negraes / Branka Hrvoj-Mihic / Mauro F.C. Lins / Katerina Semendeferi / Alysson R. Muotri -- The Next Step of Induced Pluripotent Stem Cells: Three-Dimensional Cultures and Mini-Brains / Cleber A. Trujillo / Priscilla D. Negraes / Branka Hrvoj-Mihic / Mauro F.C. Lins / Katerina Semendeferi / Alysson R. Muotri

Note continued: Limitations of Induced Pluripotent Stem Cell Model / Cleber A. Trujillo / Priscilla D. Negraes / Branka Hrvoj-Mihic / Mauro F.C. Lins / Katerina Semendeferi / Alysson R. Muotri -- Genome Editing: Creating Diseased Embryonic Stem Cells / Alysson R. Muotri / Cleber A. Trujillo / Priscilla D. Negraes / Branka Hrvoj-Mihic / Mauro F.C. Lins / Katerina Semendeferi -- Drug Discovery With Induced Pluripotent Stem Cells / Cleber A. Trujillo / Priscilla D. Negraes / Branka Hrvoj-Mihic / Mauro F.C. Lins / Katerina Semendeferi / Alysson R. Muotri -- Conclusions / Cleber A. Trujillo / Priscilla D. Negraes / Branka Hrvoj-Mihic / Mauro F.C. Lins / Katerina Semendeferi / Alysson R. Muotri -- References / Cleber A. Trujillo / Priscilla D. Negraes / Branka Hrvoj-Mihic / Mauro F.C. Lins / Katerina Semendeferi / Alysson R. Muotri

Note continued: 9.Association Strategies / Cleber A. Trujillo / Priscilla D. Negraes / Branka Hrvoj-Mihic / Mauro F.C. Lins / Katerina Semendeferi / Alysson R. Muotri -- Common Variants / Benjamin M. Neale -- Rare Variants / Benjamin M. Neale -- Conclusions / Benjamin M. Neale -- Acknowledgments / Benjamin M. Neale -- References / Benjamin M. Neale -- 10.Reconstructing Causal Network Models of Human Disease / Benjamin M. Neale -- Introduction / Eric E. Schadt -- Modeling Biological Data / Eric E. Schadt -- Causality as a Statistical Inference / Eric E. Schadt -- From Assessing Causal Relationships Among Trait Pairs to Predictive Gene Networks / Eric E. Schadt -- Building From the Bottom Up or Top Down? / Eric E. Schadt -- An Integrative Genomics Approach to Constructive Predictive Network Models / Eric E. Schadt -- Integrating Genetic Data as a Structure Before Enhancing Causal Inference in the Bayesian Network Reconstruction Process / Eric E. Schadt

Note continued: Incorporating Other -Omics Data as Network Priors in the Bayesian Network Reconstruction Process / Eric E. Schadt -- Elucidating the Complexity of Human Disease: From the Metabolic to the Psychiatric / Eric E. Schadt -- Application of Predictive Network Models to High-Throughput Screening / Eric E. Schadt -- Conclusion and Future Directions / Eric E. Schadt -- References / Eric E. Schadt -- 11.Gene Networks in Neuropsychiatric Disease / Eric E. Schadt -- Introduction / Neelroop N. Parikshak / Daniel H. Geschwind -- RNA, Protein, and Epigenetic Molecular Levels in Neurobiology / Neelroop N. Parikshak / Daniel H. Geschwind -- The Challenge of Spatial and Temporal Heterogeneity in the Central Nervous System / Neelroop N. Parikshak / Daniel H. Geschwind -- Gene Networks Provide a Framework for Neurobiological Interpretation / Neelroop N. Parikshak / Daniel H. Geschwind

Note continued: Gene Networks in Neuropsychiatric Disorders / Neelroop N. Parikshak / Daniel H. Geschwind -- Genome-Wide Approaches / Neelroop N. Parikshak / Daniel H. Geschwind -- Seed-Based Approaches / Neelroop N. Parikshak / Daniel H. Geschwind -- Protein-Protein Interaction Networks / Neelroop N. Parikshak / Daniel H. Geschwind -- Integrative Network Approaches / Neelroop N. Parikshak / Daniel H. Geschwind -- Themes From Cross-Method Comparisons / Neelroop N. Parikshak / Daniel H. Geschwind -- Conclusions and Future Directions / Neelroop N. Parikshak / Daniel H. Geschwind -- Acknowledgments / Neelroop N. Parikshak / Daniel H. Geschwind -- References / Neelroop N. Parikshak / Daniel H. Geschwind -- 12.Somatic Mosaicism and Neurological Diseases / Neelroop N. Parikshak / Daniel H. Geschwind -- Introduction / Saumya S. Jamuar / Alissa M. D'Gama / Christopher A. Walsh

Note continued: Cortical Clonal Architecture and Somatic Mutations / Saumya S. Jamuar / Alissa M. D'Gama / Christopher A. Walsh -- Somatic Mutations in Normal Brain / Saumya S. Jamuar / Alissa M. D'Gama / Christopher A. Walsh -- Somatic Mutation in Neurological Disease / Saumya S. Jamuar / Alissa M. D'Gama / Christopher A. Walsh -- "Brain-Only" Somatic Mutations / Saumya S. Jamuar / Alissa M. D'Gama / Christopher A. Walsh -- "Second-Hit" Mutations Produce Mosaicism / Saumya S. Jamuar / Alissa M. D'Gama / Christopher A. Walsh -- Neurodevelopmental Disorders Caused by Somatic Mutations / Saumya S. Jamuar / Alissa M. D'Gama / Christopher A. Walsh -- Neurological Diseases Caused or Modulated by Somatic Mutations / Saumya S. Jamuar / Alissa M. D'Gama / Christopher A. Walsh -- Types of Somatic Variants / Saumya S. Jamuar / Alissa M. D'Gama / Christopher A. Walsh -- Large-Scale Chromosomal Abnormalities / Saumya S. Jamuar / Alissa M. D'Gama / Christopher A. Walsh

Note continued: Copy Number Variants / Saumya S. Jamuar / Alissa M. D'Gama / Christopher A. Walsh -- Single-Nucleotide Variants / Saumya S. Jamuar / Alissa M. D'Gama / Christopher A. Walsh -- Tissue Type Considerations / Saumya S. Jamuar / Alissa M. D'Gama / Christopher A. Walsh -- Tools to Study Somatic Variation in the Brain / Saumya S. Jamuar / Alissa M. D'Gama / Christopher A. Walsh -- Copy Number Variants / Saumya S. Jamuar / Alissa M. D'Gama / Christopher A. Walsh -- Single-Nucleotide Variants, Including Insertions and Deletions / Saumya S. Jamuar / Alissa M. D'Gama / Christopher A. Walsh -- Conclusion / Saumya S. Jamuar / Alissa M. D'Gama / Christopher A. Walsh -- Acknowledgments / Saumya S. Jamuar / Alissa M. D'Gama / Christopher A. Walsh -- References / Saumya S. Jamuar / Alissa M. D'Gama / Christopher A. Walsh -- 13.The Molecular Landscape of the Developing Human Central Nervous System / Saumya S. Jamuar / Alissa M. D'Gama / Christopher A. Walsh

Note continued: Introduction / Nenad Sestan / Ying Zhu / John C. Silbereis / Sirisha Pochareddy / Mingfeng Li -- The Cellular and Structural Complexity of the Human Brain / John C. Silbereis / Ying Zhu / Sirisha Pochareddy / Mingfeng Li / Nenad Sestan -- General Principles of Human Neocortical Development / Ying Zhu / John C. Silbereis / Sirisha Pochareddy / Mingfeng Li / Nenad Sestan -- Neurogenesis and Neuronal Migration / John C. Silbereis / Ying Zhu / Sirisha Pochareddy / Nenad Sestan / Mingfeng Li -- Glial Cell Genesis and Differentiation / Ying Zhu / John C. Silbereis / Sirisha Pochareddy / Mingfeng Li / Nenad Sestan -- Neural Circuit Formation and Developmental Plasticity / Ying Zhu / John C. Silbereis / Mingfeng Li / Sirisha Pochareddy / Nenad Sestan -- Regional Patterning and Interhemispheric Lateralization / Ying Zhu / John C. Silbereis / Sirisha Pochareddy / Mingfeng Li / Nenad Sestan

Note continued: Transcriptional Landscape of the Developing Human Brain / Ying Zhu / John C. Silbereis / Sirisha Pochareddy / Mingfeng Li / Nenad Sestan -- Spatiotemporal Dynamics of Human Brain Transcriptome / Ying Zhu / John C. Silbereis / Sirisha Pochareddy / Mingfeng Li / Nenad Sestan -- Transcriptional Architecture Underlying Cellular and Regional Specification of the Human Brain / Ying Zhu / John C. Silbereis / Sirisha Pochareddy / Mingfeng Li / Nenad Sestan -- Transcriptional Insights Into Maturational Trajectories of the Human Neocortex / Ying Zhu / John C. Silbereis / Sirisha Pochareddy / Mingfeng Li / Nenad Sestan -- Interhemispheric Neocortical Transcriptomes / Ying Zhu / John C. Silbereis / Sirisha Pochareddy / Mingfeng Li / Nenad Sestan -- Epigenomic and Regulatory Landscapes of the Developing Human Brain / Ying Zhu / John C. Silbereis / Sirisha Pochareddy / Mingfeng Li / Nenad Sestan

Note continued: DNA Methylation in Human Brain Development / Ying Zhu / John C. Silbereis / Sirisha Pochareddy / Mingfeng Li / Nenad Sestan -- Histone Modification and Functional Regulatory Elements in Human Brain Development / Ying Zhu / John C. Silbereis / Sirisha Pochareddy / Mingfeng Li / Nenad Sestan -- Noncoding RNAs in Human Brain Development / Ying Zhu / John C. Silbereis / Sirisha Pochareddy / Mingfeng Li / Nenad Sestan -- Insights Into Psychiatric and Neurological Disorders / Ying Zhu / John C. Silbereis / Sirisha Pochareddy / Mingfeng Li / Nenad Sestan -- Conclusions and Future Directions / Ying Zhu / John C. Silbereis / Sirisha Pochareddy / Mingfeng Li / Nenad Sestan -- Acknowledgments / Ying Zhu / John C. Silbereis / Sirisha Pochareddy / Mingfeng Li / Nenad Sestan -- References / Ying Zhu / John C. Silbereis / Sirisha Pochareddy / Mingfeng Li / Nenad Sestan

Note continued: 14.Optogenetic Approaches to Neural Circuit Analysis in the Mammalian Brain / Ying Zhu / John C. Silbereis / Sirisha Pochareddy / Mingfeng Li / Nenad Sestan -- Introduction / Stephan Lammel / Gul Dolen / Robert C. Malenka -- Tools for Functional Neural Circuit Dissection / Stephan Lammel / Gul Dolen / Robert C. Malenka -- Definition of Opsins / Stephan Lammel / Gul Dolen / Robert C. Malenka -- Expression of Opsins in the Mammalian Brain / Stephan Lammel / Gul Dolen / Robert C. Malenka -- Cell Type-Specific Targeting of Opsins Using Promoters / Stephan Lammel / Gul Dolen / Robert C. Malenka -- Cell Type-Specific Targeting of Opsins Using Cre/loxP Recombinase / Stephan Lammel / Gul Dolen / Robert C. Malenka -- Intersectional Approaches / Stephan Lammel / Gul Dolen / Robert C. Malenka -- Functional Circuit Analysis / Stephan Lammel / Gul Dolen / Robert C. Malenka

Note continued: Ex Vivo Synaptic Input Specificity / Stephan Lammel / Gul Dolen / Robert C. Malenka -- In Vivo Neural Circuit Analysis in Freely Moving Animals / Stephan Lammel / Gul Dolen / Robert C. Malenka -- Translational Medicine / Stephan Lammel / Gul Dolen / Robert C. Malenka -- Conclusions / Stephan Lammel / Gul Dolen / Robert C. Malenka -- References / Stephan Lammel / Gul Dolen / Robert C. Malenka -- 15.Brain Imaging With Magneto-encephalography During Rest and During Speech and Language Processing / Stephan Lammel / Gul Dolen / Robert C. Malenka -- Brain Imaging With Magnetoencephalography (MEG) / Srikantan S. Nagarajan / Kamalini G. Ranasinghe / Keith A. Vossel -- Sensing the Brain's Magnetic Fields / Srikantan S. Nagarajan / Kamalini G. Ranasinghe / Keith A. Vossel -- From Sensing to Imaging / Srikantan S. Nagarajan / Kamalini G. Ranasinghe / Keith A. Vossel

Note continued: Forward Models Describing Brain Activity and Measurements / Srikantan S. Nagarajan / Kamalini G. Ranasinghe / Keith A. Vossel -- Inverse Models for Reconstructing Brain Activity From Measurements / Srikantan S. Nagarajan / Kamalini G. Ranasinghe / Keith A. Vossel -- Sources of Noise in Magnetoencephalography / Srikantan S. Nagarajan / Kamalini G. Ranasinghe / Keith A. Vossel -- Temporal and Spatial Resolution of Magnetoencephalography Imaging / Srikantan S. Nagarajan / Kamalini G. Ranasinghe / Keith A. Vossel -- From Single-Subject Reconstructions to Group-Level Inference / Srikantan S. Nagarajan / Kamalini G. Ranasinghe / Keith A. Vossel -- Magnetoencephalography Studies in Aging and Dementia / Srikantan S. Nagarajan / Kamalini G. Ranasinghe / Keith A. Vossel -- Resting Magnetoencephalography Studies in Aging and Dementia / Srikantan S. Nagarajan / Kamalini G. Ranasinghe / Keith A. Vossel

Note continued: Activation Magnetoencephalography Studies in Aging and Dementia / Srikantan S. Nagarajan / Kamalini G. Ranasinghe / Keith A. Vossel -- Summary and Conclusions / Srikantan S. Nagarajan / Kamalini G. Ranasinghe / Keith A. Vossel -- References / Srikantan S. Nagarajan / Kamalini G. Ranasinghe / Keith A. Vossel -- 16.Resting-State Functional MRI: A Novel Tool for Understanding Brain Networks in Neuropsychiatric Disorders / Srikantan S. Nagarajan / Kamalini G. Ranasinghe / Keith A. Vossel -- A Brief History of Resting-State Functional MRI / Michael Greicius -- Healthy Skepticism Drives Deeper Explorations / Michael Greicius -- Attributes of Resting-State Networks / Michael Greicius -- Default-Mode and Salience Networks / Michael Greicius -- Applications to Brain Disease / Michael Greicius -- Future Directions / Michael Greicius -- References / Michael Greicius -- 17.Neuroimaging Advances in Alzheimer's Disease / Michael Greicius

Note continued: Abbreviations / Daniel R. Schonhaut / Gil D. Rabinovici -- Introduction / Daniel R. Schonhaut / Gil D. Rabinovici -- Alzheimer's Disease Defined / Daniel R. Schonhaut / Gil D. Rabinovici -- Imaging Characteristics of Alzheimer's Disease / Daniel R. Schonhaut / Gil D. Rabinovici -- Structural MRI / Daniel R. Schonhaut / Gil D. Rabinovici -- Functional MRI / Daniel R. Schonhaut / Gil D. Rabinovici -- [18F]Fluoro-2-Deoxy-o-Glucose Positron Emission Tomography / Daniel R. Schonhaut / Gil D. Rabinovici -- Amyloid Positron Emission Tomography / Daniel R. Schonhaut / Gil D. Rabinovici -- Tau Positron Emission Tomography / Daniel R. Schonhaut / Gil D. Rabinovici -- Progression of Neuroimaging Abnormalities: An Amyloid Cascade? / Daniel R. Schonhaut / Gil D. Rabinovici -- Preclinical Alzheimer's Disease / Daniel R. Schonhaut / Gil D. Rabinovici -- Mild Cognitive Impairment / Daniel R. Schonhaut / Gil D. Rabinovici

Note continued: Dementia and Limitations of the Amyloid Cascade Hypothesis / Daniel R. Schonhaut / Gil D. Rabinovici -- Underlying Mechanisms of Alzheimer's Disease Pathology / Daniel R. Schonhaut / Gil D. Rabinovici -- Amyloid Plaques Form in Regional Hubs / Daniel R. Schonhaut / Gil D. Rabinovici -- Tau Spreads Through Functional Networks / Daniel R. Schonhaut / Gil D. Rabinovici -- Conclusions / Daniel R. Schonhaut / Gil D. Rabinovici -- References / Daniel R. Schonhaut / Gil D. Rabinovici -- 18.Progressive Supranuclear Palsy and Related Parkinsonian Disorders / Daniel R. Schonhaut / Gil D. Rabinovici -- Introduction / Jesse A. Brown / William W. Seeley -- Each Neurodegenerative Syndrome Reflects a Network / Jesse A. Brown / William W. Seeley -- Class-Wide Principles of Network-Based Neurodegeneration / Jesse A. Brown / William W. Seeley -- Parkinsonian Syndromes: Parkinson Disease and Others / Jesse A. Brown / William W. Seeley

Note continued: Parkinson Disease: Clinical and Anatomical Features / Jesse A. Brown / William W. Seeley -- Progressive Supranuclear Palsy Syndrome: Clinical Features / Jesse A. Brown / William W. Seeley -- Corticobasal Syndrome: Clinical Features / Jesse A. Brown / William W. Seeley -- Network Architecture of Neurodegenerative Parkinsonian Syndromes / William W. Seeley / Jesse A. Brown -- Network Architecture of Progressive Supranuclear Palsy Syndrome / Jesse A. Brown / William W. Seeley -- Network Architecture of Corticobasal Syndrome / Jesse A. Brown / William W. Seeley -- Clinicopathological Correlation in Progressive Supranuclear Palsy and Corticobasal Degeneration / Jesse A. Brown / William W. Seeley -- Multiple Proteinopathies Can Cause Progressive Supranuclear Palsy Syndrome and Corticobasal Syndrome / Jesse A. Brown / William W. Seeley -- Pathological Causes of Progressive Supranuclear Palsy Syndrome / Jesse A. Brown / William W. Seeley

Note continued: Pathological Causes of Corticobasal Syndrome / Jesse A. Brown / William W. Seeley -- Progressive Supranuclear Palsy and Corticobasal Degeneration Histopathology Can Cause Multiple Clinical Syndromes / Jesse A. Brown / William W. Seeley -- Genetic Factors in Progressive Supranuclear Palsy and Corticobasal Degeneration / Jesse A. Brown / William W. Seeley -- Rare Monogenic Causes / Jesse A. Brown / William W. Seeley -- Risk Factors / Jesse A. Brown / William W. Seeley -- Genome-Wide Association Studies / Jesse A. Brown / William W. Seeley -- Conclusion / Jesse A. Brown / William W. Seeley -- Acknowledgment / Jesse A. Brown / William W. Seeley -- References / Jesse A. Brown / William W. Seeley -- 19.A New Neuroanatomy of Basal Ganglia Circuitry / Jesse A. Brown / William W. Seeley -- Abbreviations / Nicholas AuYong / Adrienne M. Keener / Yvette M. Bordelon / Carlos Portera-Cailliau / Nader Pouratian

Note continued: Anatomic Overview of Basal Ganglia / Nicholas AuYong / Adrienne M. Keener / Yvette M. Bordelon / Carlos Portera-Cailliau / Nader Pouratian -- Clinical Basal Ganglia Disorders / Nicholas AuYong / Adrienne M. Keener / Yvette M. Bordelon / Carlos Portera-Cailliau / Nader Pouratian -- Parkinson Disease / Nicholas AuYong / Adrienne M. Keener / Yvette M. Bordelon / Carlos Portera-Cailliau / Nader Pouratian -- Huntington Disease / Nicholas AuYong / Adrienne M. Keener / Yvette M. Bordelon / Carlos Portera-Cailliau / Nader Pouratian -- Classical Basal Ganglia Microanatomy / Nicholas AuYong / Adrienne M. Keener / Yvette M. Bordelon / Carlos Portera-Cailliau / Nader Pouratian -- Probing Basal Ganglia Circuitry in Animal Models / Carlos Portera-Cailliau / Nader Pouratian / Nicholas AuYong / Adrienne M. Keener / Yvette M. Bordelon -- Recordings in Animals / Nicholas AuYong / Adrienne M. Keener / Yvette M. Bordelon / Carlos Portera-Cailliau / Nader Pouratian

Note continued: Ablation Studies / Nicholas AuYong / Adrienne M. Keener / Yvette M. Bordelon / Carlos Portera-Cailliau / Nader Pouratian -- Optogenetics / Nicholas AuYong / Adrienne M. Keener / Yvette M. Bordelon / Carlos Portera-Cailliau / Nader Pouratian -- Animal Studies Reveal Flaws in the Classical Model of Basal Ganglia Circuitry / Nicholas AuYong / Adrienne M. Keener / Yvette M. Bordelon / Carlos Portera-Cailliau / Nader Pouratian -- Emerging Techniques to Study Basal Ganglia Circuitry in Animals / Nicholas AuYong / Adrienne M. Keener / Yvette M. Bordelon / Carlos Portera-Cailliau / Nader Pouratian -- Calcium Imaging / Nicholas AuYong / Adrienne M. Keener / Yvette M. Bordelon / Carlos Portera-Cailliau / Nader Pouratian -- Voltage Sensors / Nicholas AuYong / Adrienne M. Keener / Yvette M. Bordelon / Carlos Portera-Cailliau / Nader Pouratian -- Optogenetics / Nicholas AuYong / Adrienne M. Keener / Yvette M. Bordelon / Carlos Portera-Cailliau / Nader Pouratian

Note continued: Striatal Interneurons / Nicholas AuYong / Adrienne M. Keener / Yvette M. Bordelon / Carlos Portera-Cailliau / Nader Pouratian -- Probing Basal Ganglia Circuitry in Humans: Invasive Physiology / Nicholas AuYong / Adrienne M. Keener / Yvette M. Bordelon / Carlos Portera-Cailliau / Nader Pouratian -- Noninvasive Studies of Basal Ganglia Circuitry in Humans / Nicholas AuYong / Adrienne M. Keener / Yvette M. Bordelon / Carlos Portera-Cailliau / Nader Pouratian -- Conclusions / Nicholas AuYong / Adrienne M. Keener / Yvette M. Bordelon / Carlos Portera-Cailliau / Nader Pouratian -- References / Yvette M. Bordelon / Carlos Portera-Cailliau / Nader Pouratian / Nicholas AuYong / Adrienne M. Keener -- 20.Brainstem Circuitry and Emotions / Nicholas AuYong / Adrienne M. Keener / Yvette M. Bordelon / Carlos Portera-Cailliau / Nader Pouratian -- The Structural Organization of the Brainstem / Panos Theofilas / Helmut Heinsen / Lea T. Grinberg

Note continued: Reticular Formation / Panos Theofilas / Helmut Heinsen / Lea T. Grinberg -- Chemical Properties of the Reticular Nuclei / Panos Theofilas / Helmut Heinsen / Lea T. Grinberg -- Reticular Formation Modulates Behavior / Panos Theofilas / Helmut Heinsen / Lea T. Grinberg -- Sleep Cycle / Panos Theofilas / Helmut Heinsen / Lea T. Grinberg -- Mood / Panos Theofilas / Helmut Heinsen / Lea T. Grinberg -- Conclusion / Panos Theofilas / Helmut Heinsen / Lea T. Grinberg -- References / Panos Theofilas / Helmut Heinsen / Lea T. Grinberg -- 21.Apathy: Frontal and Basal Ganglia Circuits / Panos Theofilas / Helmut Heinsen / Lea T. Grinberg -- Introduction / Pongsatorn Paholpak / Mario F. Mendez -- Definition and Diagnosis of Apathy / Pongsatorn Paholpak / Mario F. Mendez -- Clinical Variants, Diagnosis, and Measurement of Apathy / Pongsatorn Paholpak / Mario F. Mendez -- Measurement and Rating Scale / Pongsatorn Paholpak / Mario F. Mendez

Note continued: Molecular and Neuroanatomical Basis of Apathy / Pongsatorn Paholpak / Mario F. Mendez -- Prefrontal Cortex in Primates / Pongsatorn Paholpak / Mario F. Mendez -- Prefrontal Cortex in Humans / Pongsatorn Paholpak / Mario F. Mendez -- Motivation and Reward System: Basal Ganglia Structures and Corticostriatal Loop / Pongsatorn Paholpak / Mario F. Mendez -- Structural and Functional Connectivity in Apathy / Pongsatorn Paholpak / Mario F. Mendez -- Dopamine Regulation in Motivation and Reward System / Pongsatorn Paholpak / Mario F. Mendez -- Apathy in Neuropsychiatric Diseases / Pongsatorn Paholpak / Mario F. Mendez -- Traumatic Brain Injury / Pongsatorn Paholpak / Mario F. Mendez -- Schizophrenia / Pongsatorn Paholpak / Mario F. Mendez -- Stroke / Pongsatorn Paholpak / Mario F. Mendez -- Parkinson Disease / Mario F. Mendez / Pongsatorn Paholpak -- Huntington Disease / Pongsatorn Paholpak / Mario F. Mendez

Note continued: Alzheimer Dementia / Pongsatorn Paholpak / Mario F. Mendez -- Frontotemporal Dementia / Pongsatorn Paholpak / Mario F. Mendez -- Genetics Studies of Apathy / Pongsatorn Paholpak / Mario F. Mendez -- Huntington Disease / Pongsatorn Paholpak / Mario F. Mendez -- Parkinson Disease and Parkinsonism / Pongsatorn Paholpak / Mario F. Mendez -- Alzheimer Dementia / Pongsatorn Paholpak / Mario F. Mendez -- Frontotemporal Dementia / Pongsatorn Paholpak / Mario F. Mendez -- Schizophrenia / Pongsatorn Paholpak / Mario F. Mendez -- Summary / Pongsatorn Paholpak / Mario F. Mendez -- References / Pongsatorn Paholpak / Mario F. Mendez -- 22.Emotional Dysfunction in Psychopathology and Neuropathology: Neural and Genetic Pathways / Pongsatorn Paholpak / Mario F. Mendez -- Emotional Dysfunction in Psychopathology and Neuropathology: Neural and Genetic Pathways / Virginia E. Sturm / Claudia M. Haase / Robert W. Levenson

Note continued: Emotions and Emotional Processes Emotions: Short and Discrete / Virginia E. Sturm / Claudia M. Haase / Robert W. Levenson -- Emotional Processes / Virginia E. Sturm / Claudia M. Haase / Robert W. Levenson -- Emotional Reactivity / Virginia E. Sturm / Claudia M. Haase / Robert W. Levenson -- Emotional Regulation / Virginia E. Sturm / Claudia M. Haase / Robert W. Levenson -- Emotional Affiliation / Virginia E. Sturm / Claudia M. Haase / Robert W. Levenson -- Emotional Functioning: Neural Pathways / Virginia E. Sturm / Claudia M. Haase / Robert W. Levenson -- Emotional Reactivity / Virginia E. Sturm / Claudia M. Haase / Robert W. Levenson -- Anterior Cingulate Cortex / Virginia E. Sturm / Claudia M. Haase / Robert W. Levenson -- Amygdala / Virginia E. Sturm / Claudia M. Haase / Robert W. Levenson -- Hypothalamus / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Brain Stem / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase

Note continued: Insula / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Emotion Regulation / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Ventrolateral Prefrontal Cortex / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Dorsolateral Prefrontal Cortex / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Anterior Midcingulate Cortex / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Inferior Parietal Lobe / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Emotional Affiliation / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Superior Temporal Sulcus / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Dorsomedial Prefrontal Cortex / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Ventral Striatum / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Medial Orbitofrontal Cortex / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase

Note continued: Septal Area / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Emotion Functioning: Genetic Pathways / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Model of the Genetic Pathway / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Emotional Reactivity / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Serotonin-Related Genes / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Other Genes / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Emotion Regulation / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Dopamine-Related Genes / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Other Genes / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Emotional Affiliation / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Oxytocin-Related Genes / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase

Note continued: Other Genes and Affiliation / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Neural and Genetic Pathways: Clinical Implications / Virginia E. Sturm / Claudia M. Haase / Robert W. Levenson -- Emotional Dysfunction in Psychopathology and Neuropathology / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Emotional Reactivity / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Emotion Regulation / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Emotional Affiliation / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Emotion in Diagnosis / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Psychopathology: Diagnostic and Statistical Manual / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Psychopathology: Research Domain Criteria / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Neuropathology / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase

Note continued: Emotion in Treatment / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- References / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- 23.The Anatomy of Delusion / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Introduction and Definition / Georges Naasan -- Phenomenology and Anatomy / Georges Naasan -- The Two-Factor Hypothesis and the Role of the Right Prefrontal Cortex / Georges Naasan -- Attention Bias and Faulty Assignment of Salience to External Stimuli: The "Aberrant Salience" Model / Georges Naasan -- The Theory of Mind in People With Delusions / Georges Naasan -- Content-Specific Delusions / Georges Naasan -- Paranoid Delusions / Georges Naasan -- The Capgras Delusion / Georges Naasan -- Genetics / Georges Naasan -- References / Georges Naasan -- 24.Beyond Dopamine: The Role of the Serotonergic System and Treatments in Understanding and Treating Visual Hallucinations in Parkinson Disease / Georges Naasan

Note continued: Simple Versus Complex Visual Hallucinations / Andrew Evans / Ramon Mocellin / Dennis Velakoulis / Mark Walterfang -- The Visual Pathway and Mechanisms of Disruption Leading to Visual Hallucinations / Dennis Velakoulis / Mark Walterfang / Andrew Evans / Ramon Mocellin -- Complex Visual Hallucinations: The Role of Lesion Location / Dennis Velakoulis / Mark Walterfang / Andrew Evans / Ramon Mocellin -- Synucleinopathy and Visual Hallucinations / Dennis Velakoulis / Mark Walterfang / Andrew Evans / Ramon Mocellin -- The Origins of Visual Hallucinations in Parkinson Disease / Dennis Velakoulis / Mark Walterfang / Andrew Evans / Ramon Mocellin -- The Serotonergic System and Visual Hallucinations / Dennis Velakoulis / Mark Walterfang / Andrew Evans / Ramon Mocellin -- Anatomy of the Serotonergic System / Dennis Velakoulis / Mark Walterfang / Andrew Evans / Ramon Mocellin

Note continued: Psilocybin and the Serotonergic System / Dennis Velakoulis / Mark Walterfang / Andrew Evans / Ramon Mocellin -- Parkinson Disease and the Serotonergic System / Dennis Velakoulis / Mark Walterfang / Andrew Evans / Ramon Mocellin -- Pharmacological Interventions for Visual Hallucinations in Parkinson Disease / Dennis Velakoulis / Mark Walterfang / Andrew Evans / Ramon Mocellin -- D2 Antagonism / Dennis Velakoulis / Mark Walterfang / Andrew Evans / Ramon Mocellin -- Serotonin Antagonism / Dennis Velakoulis / Mark Walterfang / Andrew Evans / Ramon Mocellin -- Summary / Dennis Velakoulis / Mark Walterfang / Andrew Evans / Ramon Mocellin -- References / Dennis Velakoulis / Mark Walterfang / Andrew Evans / Ramon Mocellin -- 25.Risk Overlap Between Clinical Disorders / Dennis Velakoulis / Mark Walterfang / Andrew Evans / Ramon Mocellin -- Introduction / Patrick F. Sullivan -- Clinical Neuroscience, Neurology, and Psychiatry / Patrick F. Sullivan

There are no comments on this title.

to post a comment.

No. of hits (from 9th Mar 12) :

Powered by Koha