Functional neuromarkers for psychiatry : applications for diagnosis and treatment / Juri D. Kropotov.

Includes bibliographical references and index.

Print version record.

Cover; Title Page; Copyright Page; Contents; Acknowledgments; Introduction; Two recent events that may change psychiatry; Mental illness as a challenge to healthcare systems; DSM and ICD as dictionaries of psychopathology; The hurdles to overcome; From symptoms to neuronal circuits; From "decade of the brain" to "decade of translation"; Concept of biomarker; Neuromarkers and neuroimaging; Endophenotype in psychiatry; Extended endophenotype; Genetic and epigenetic factors; Common psychiatric diseases are not Mendelian disorders; Risk factors; Search for nonpharmaceutical methods of treatment.

Training in clinical neuroscienceHuman Brain Indices database as a source of reference; Personal motives; Part 1 -- Methods of Assessing Neuromarkers; Chapter 1.1 -- Theory of Measurement; True and observed scores, errors; Reliability; Validity; Distribution across population; Percentiles and z scores; Sensitivity and specificity; Effect size; Requirements for introducing a neuromarker into clinical practice; Chapter 1.2 -- Psychometrics and Neuropsychological Assessment; Psychological models; Neuropsychological testing; Supervisory attentional system model; Operations of attentional control.

Dual mechanisms of cognitive controlGeneral factor; Reaction time; Reaction time variability; Continuous performance tasks; Infraslow fluctuations in performance; Big 5 model; Chapter 1.3 -- Functional Magnetic Resonance Imaging; Talairach atlas; Montreal Neurological Institute atlas; Physical basis of magnetic resonance imaging; Functional magnetic resonance imaging; BOLD response; BOLD infralow fluctuations; 0.1-Hz hemodynamic oscillations; Processing steps in functional imaging; Activation maps of fMRI; Model-dependent correlational methods; Model-free correlational methods.

Task-negative and task-positive networksFunctional connectivity and diffuse tensor imaging; Test-retest reliability; fMRI in neurological practice; Challenges for clinical fMRI; Chapter 1.4 -- Positron Emission Tomography; Physical basis of positron emission tomography; Neuroreceptors; Test-retest reliability; Neurotransmitters and receptor imaging in clinics; Chapter 1.5 -- Spontaneous Electroencephalogram; How an electroencephalogram is measured; Montages; Electrical events in the cortex; 10-20 International System; Frequency bands.

Electroencephalograms as a reflection of cortical self-regulationVoltage-gated ion channels; Nonbrain events (artifacts) in electroencephalograms; Spectral analysis of electroencephalograms; Interindividual differences; Wavelet transformation; Coherence; Neuronal sources of electrical currents; Intracortical connectivity; Cortical focus and spikes; Volume conductance; Inverse problem: dipole approximation; Inverse problem: nonparametric solutions; Current source density; Blind source separation; Independent component analysis.