Insights to neuroimmune biology / edited by Istvan Berczi.

Online resource; title from PDF title page (Ebsco, viewed February 22, 2016).

Includes bibliographical references and index.

Insights to Neuroimmune Biology, Second Edition discusses the systemic regulatory network, coordination, organization, and interpretation of the rapidly accumulating knowledge on the topic of neuroimmune biology, with an ultimate goal of helping readers understand the function of higher organisms, including man, in their entire complexity. This publication provides assessments and interpretations of accumulated experimental evidence, enabling the scientific community to keep abreast of essential advancements of existing knowledge as we search for greater understanding of the biology of higher organisms.

Cover ; Title page; Copyright; Table of Contents ; List of Contributors; Foreword; Preface; Part 1 -- Introduction: Neuroimmune Regulation in Health and Disease ; Chapter 1 -- Neuroimmune Regulation in Health and Disease; 1 -- Introduction; 1.1 -- Health; 2 -- Disease; 2.1 -- A Brief History; 2.2 -- HPA Axis and Disease; 2.2.1 -- New Observations Showing that Stress may be Beneficial; 2.2.2 -- Early Life Programming by GCs; 2.2.3 -- Schizophrenia; 2.2.4 -- Alzheimer's Disease (AD); 2.2.5 -- Huntington's Disease (HD); 2.2.6 -- Multiple Sclerosis (MS); 2.2.7 -- Anxiety and Depression.

2.2.8 -- Major Depressive Disorder2.2.9 -- Various Other Forms of Depression; 2.2.10 -- Inflammation; 2.2.11 -- Various Other Conditions; 2.2.12 -- Agents that Influence the HPA axis; 2.2.13 -- Regulatory Mechanisms of HPA Axis; 3 -- Discussion; 4 -- Conclusions; References; Chapter 2 -- The Neuroimmune Supersystem; 1 -- Introduction; 2 -- The neuroimmune supersystem; 3 -- Immunocompetence; 3.1 -- Adaptive Immunocompetence; 3.2 -- Innate or Natural Immunocompetence; 4 -- Growth signaling in the IS; 4.1 -- Signaling by GLH; 4.2 -- Antigen Presentation; 5 -- Immune neuroendocrine feedback signals.

6 -- Homeostasis, the immune-neuroendocrine circuitry6.1 -- Immunoregulation by the HPA Axis; 7 -- Acute illness; 7.1 -- Neurogenic Inflammation; 7.2 -- The Acute Phase Response (APR); 8 -- Healing; 9 -- Conclusions: the biological significance of NISS; References; Part 2 -- Hypothalamic Immunoregulation ; Chapter 3 -- Multifactorial Regulation of GLH Hormones; 1 -- Immunoregulation by the pituitary gland; 2 -- Immunoregulation by growth and lactogenic hormones; 2.1 -- Immunoregulatory Pathways; 2.1.1 -- Thymus; 2.1.2 -- Receptors for GLH in Various Cells and Tissues; 2.1.3 -- Immune Reactions.

2.1.4 -- Acute Febrile Illness (Acute phase response (APR))3 -- Dopamine in neuroimmune biology; 3.1 -- Dopamine Receptors in Tissues and Cells; 3.2 -- Conserved Dopamine Neurotrophic Factor; 3.3 -- BRC; 3.4 -- Neuropeptide; 3.5 -- Interleukin; 4 -- Immunoregulation by dopamine; 5 -- Oxytocin and ghrelin in immunity; 5.1 -- Ghrelin (GRL) and Immunity; 6 -- Conclusions; References; Chapter 4 -- An Update on Neural Regulators of the Hypothalamic-Pituitary-Adrenal Axis; 1 -- Corticotropin-releasing hormone; 1.1 -- Proopiomelanocortin; 2 -- Neuropeptide regulators of the HPA axis; 2.1 -- Urocortin.

2.2 -- Catecholamines2.3 -- Apelin; 2.4 -- Cholecystokinin; 2.5 -- Leptin; 2.6 -- Leukotriens; 2.7 -- Natriuretic Peptide; 2.8 -- Neuromedins; 2.9 -- Neuropeptides; 2.10 -- Nociceptin/Orpanin; 2.11 -- PACAP; 2.12 -- Opioid Peptides; 2.13 -- Orexin; 2.14 -- Relaxin; 2.15 -- Sauvagine and Urotensin; 2.16 -- SCP and SRP; 2.17 -- Vasotocin; 3 -- CRH and the CNS; 4 -- CRH-Receptors 1 and 2 (CHR1, 2) and UCN Receptors; 5 -- Hormonal immunoregulation and the HPA axis; 5.1 -- Immunoregulaton by the Pituitary Gland; 5.2 -- Endotoxin Shock; 5.3 -- Immunoregulation by the Submandibular Salivary Gland.

5.4 -- Combination Immunotherapy of Cancer.